2. Epidemiology

  1. David Isaacs

Published Online: 22 NOV 2013

DOI: 10.1002/9781118636657.ch2

Evidence-Based Neonatal Infections

Evidence-Based Neonatal Infections

How to Cite

Isaacs, D. (2013) Epidemiology, in Evidence-Based Neonatal Infections, John Wiley & Sons Ltd, Chichester, UK. doi: 10.1002/9781118636657.ch2

Publication History

  1. Published Online: 22 NOV 2013
  2. Published Print: 18 DEC 2013

ISBN Information

Print ISBN: 9780470654606

Online ISBN: 9781118636657



  • chorioamnionitis;
  • early-onset infection;
  • early-onset sepsis;
  • epidemiology;
  • late-onset infection;
  • late-onset sepsis;
  • neonatal infections


Neonatal infections are an important and sadly neglected cause of mortality and morbidity globally. This chapter discusses the epidemiology of early- and late-onset neonatal infections. Knowledge of the incidence of neonatal infections is important for planning preventive and intervention strategies and for comparisons within and between countries, which can help inform clinical practice and help assess the quality of care. The reported incidence of neonatal infection depends on how neonatal infection is defined and reported. Methicillin-resistant Staphylococcus aureus (MRSA), originally confined to hospitals or patients associated with hospitals, is a common community-acquired pathogen in many countries and can colonize pregnant women and cause both early- and late-onset neonatal infections. Clinical chorioamnionitis, with signs such as fever, tachycardia, uterine tenderness and foul-smelling amniotic fluid, occurs in anything from1% to 10% or more of pregnancies, depending on the population studied.