2. Rapidly Progressive Dementia and its Mimics

  1. Joseph F. Quinn MD
  1. Amy May Lin Quek and
  2. Andrew McKeon

Published Online: 25 OCT 2013

DOI: 10.1002/9781118656082.ch2

Dementia

Dementia

How to Cite

Quinn, J. F. (2013) Rapidly Progressive Dementia and its Mimics, in Dementia, John Wiley & Sons Ltd, Oxford. doi: 10.1002/9781118656082.ch2

Author Information

  1. Department of Neurology, Oregon Health and Science University, Portland VA Medical Center, Portland, OR, USA

Author Information

  1. Department of Laboratory Medicine and Pathology, USA

Publication History

  1. Published Online: 25 OCT 2013
  2. Published Print: 13 NOV 2013

ISBN Information

Print ISBN: 9780470674246

Online ISBN: 9781118656082

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Keywords:

  • rapidly;
  • progressive;
  • dementia;
  • degenerative;
  • autoimmune;
  • paraneoplastic;
  • reversible;
  • inflammatory;
  • vasculitis;
  • lymphoma

Summary

A patient with rapidly progressive dementia (RPD) requires a detailed and expedited evaluation, in particular to evaluate for treatable causes. While Creutzfeldt–Jakob disease (CJD) is a common cause, many patients with potentially treatable disorders are misdiagnosed with this disease. The increasing recognition of autoimmune CNS disorders as a treatable cause of RPD has been facilitated by the availability of neural-specific autoantibody markers such as potassium channel complex and NMDA receptor antibodies.