5. Depression

Cause or Complication of Cognitive Decline?

  1. Joseph F. Quinn MD
  1. David Mansoor,
  2. Sahana Misra and
  3. Linda Ganzini

Published Online: 25 OCT 2013

DOI: 10.1002/9781118656082.ch5



How to Cite

Quinn, J. F. (2013) Depression, in Dementia, John Wiley & Sons Ltd, Oxford. doi: 10.1002/9781118656082.ch5

Author Information

  1. Department of Neurology, Oregon Health and Science University, Portland VA Medical Center, Portland, OR, USA

Author Information

  1. Portland Veterans Affairs Medical Center, Oregon Health and Science University, USA

Publication History

  1. Published Online: 25 OCT 2013
  2. Published Print: 13 NOV 2013

ISBN Information

Print ISBN: 9780470674246

Online ISBN: 9781118656082



  • depression;
  • dementia;
  • Alzheimer's disease;
  • pseudodementia;
  • apathy;
  • vascular;
  • cortisol;
  • suicide;
  • antidepressant;
  • psychostimulant


Depression may be a risk factor, prodrome, correlate or outcome of dementia. Proposed pathways linking depression with dementia include vascular disease, hippocampal atrophy, and proinflammatory changes. Depression is neither a normal nor expected development in old age, but the prevalence increases with increasing burden of medical illness in the older patient. New depression in old age often portends development of dementia.