6. Mild Cognitive Impairment

  1. Joseph F. Quinn MD
  1. Ranjan Duara1,2,3,
  2. David A. Loewenstein1,2,
  3. Clinton Wright2,
  4. Elizabeth Crocco2 and
  5. Daniel Varon1,3

Published Online: 25 OCT 2013

DOI: 10.1002/9781118656082.ch6



How to Cite

Quinn, J. F. (2013) Mild Cognitive Impairment, in Dementia, John Wiley & Sons Ltd, Oxford. doi: 10.1002/9781118656082.ch6

Author Information

  1. Department of Neurology, Oregon Health and Science University, Portland VA Medical Center, Portland, OR, USA

Author Information

  1. 1

    Wien Center for Alzheimer's Disease and Memory Disorders, Mount Sinai Medical Center, USA

  2. 2

    Departments of Neurology and Psychiatry and Behavioral Sciences, University of Miami, Miller School of Medicine, USA

  3. 3

    Department of Neurology, Herbert Wertheim College of Medicine, Florida International University, USA

Publication History

  1. Published Online: 25 OCT 2013
  2. Published Print: 13 NOV 2013

ISBN Information

Print ISBN: 9780470674246

Online ISBN: 9781118656082



  • mild cognitive impairment;
  • MCI;
  • Alzheimer's disease;
  • prodromal forms;
  • dementia


The syndrome of Mild Cognitive Impairment (MCI) now serves as the foundation on which criteria for a diagnosis of prodromal forms of various dementias can be developed. It is known that neuropathological changes of diseases, such as Alzheimer's disease (AD), may be present years or even decades before the onset of the clinical manifestations of the disease. Cognitive and functional reserve capacity, genetic factors and medical (especially cerebrovascular) co-morbidity may determine the onset of the clinical syndrome. It appears likely that disease-modifying treatments for AD will become available in the near future, providing hope that the disease process will be arrested or reversed if treatment is initiated at a very early stage. Specific inclusionary and exclusionary criteria, cognitive tests and biomarkers could be used to enhance diagnostic accuracy for each prodromal form of dementia. In this chapter we provide the background for the recognition, diagnosis and clinical management and prevention of these conditions that may lead to specific forms of dementia.