11. Diagnostic and Therapeutic Mesenchymal Stem Cells for Breast Cancer Treatment

  1. Khalid Shah
  1. Róisín Dwyer

Published Online: 9 AUG 2013

DOI: 10.1002/9781118660423.ch11

Stem Cell Therapeutics for Cancer

Stem Cell Therapeutics for Cancer

How to Cite

Dwyer, R. (2013) Diagnostic and Therapeutic Mesenchymal Stem Cells for Breast Cancer Treatment, in Stem Cell Therapeutics for Cancer (ed K. Shah), John Wiley & Sons, Inc, Hoboken, NJ. doi: 10.1002/9781118660423.ch11

Editor Information

  1. Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA

Author Information

  1. Discipline of Surgery, School of Medicine, National University of Ireland Galway, Galway, Ireland

Publication History

  1. Published Online: 9 AUG 2013
  2. Published Print: 7 OCT 2013

ISBN Information

Print ISBN: 9781118282427

Online ISBN: 9781118660423

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Keywords:

  • breast cancer;
  • immune system;
  • mesenchymal stem cells (MSCs);
  • tumor-homing capacity

Summary

It is estimated that there will be approximately 235,000 new breast cancer cases in the United States in 2013. The majority of research in this area initially employed analysis techniques for detection of MSCs ex vivo following animal necropsy and tissue harvest. This study reported no detrimental effect of the nanoparticles on MSC differentiation potential, proliferation, survival, or migration. Along with alternate luciferase-based imaging of the MSCs and prostate cancer cells, this study combined the properties of MSCs as vehicles for the angiostatic agent with their osteogenic potential. We recently employed SPECT imaging in combination with radionuclide therapy in this setting. This study further highlighted the importance of tracking MSC migration in real time, as well as the advantage of being able to perform a pretherapy scan to confirm tumor-targeted MSC-NIS engraftment before administration of I. The majority of studies to date have shown that human MSCs are stable.