16. Infectious Agents Transmitted by Transfusion

  1. Harvey G. Klein MD1 and
  2. David J. Anstee PhD, FRCPath, FMedSci2

Published Online: 30 NOV 2013

DOI: 10.1002/9781118689943.ch16

Mollison's Blood Transfusion in Clinical Medicine, Twelfth Edition

Mollison's Blood Transfusion in Clinical Medicine, Twelfth Edition

How to Cite

Klein, H. G. and Anstee, D. J. (eds) (2014) Infectious Agents Transmitted by Transfusion, in Mollison's Blood Transfusion in Clinical Medicine, Twelfth Edition, John Wiley & Sons, Ltd, Oxford, UK. doi: 10.1002/9781118689943.ch16

Editor Information

  1. 1

    Chief, Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD, USA

  2. 2

    Director of the Bristol Institute for Transfusion Sciences, NHS Blood and Transplant; Honorary Professor of Transfusion Sciences, University of Bristol, Bristol, UK

Publication History

  1. Published Online: 30 NOV 2013
  2. Published Print: 24 JAN 2014

ISBN Information

Print ISBN: 9781405199407

Online ISBN: 9781118689943



  • cytomegalovirus (CMV);
  • Epstein—Barr virus (EBV);
  • human immunodeficiency virus (HIV);
  • human parvovirus (HPV) B19;
  • infectious agents;
  • microbiological agents;
  • screening assays;
  • transfusion


Most death and disability related to blood transfusion worldwide is caused by the transmission of infectious agents. The need to develop sensitive and specific assays amenable to mass screening and automation has become apparent. Measures to exclude human immunodeficiency virus (HIV) -infected subjects from blood donor rolls are among the most important means of preventing the spread of AIDS by transfusion. Cytomegalovirus (CMV) is one of the infectious agents most frequently transmitted by transfusion. Infection with Epstein—Barr virus (EBV), a herpes virus-like CMV, is endemic throughout the world. Human parvovirus (HPV) B19 infection has long been known to cause erythema infectiosum, common febrile exanthem of childhood. Dengue is the most common Arboviral disease in humans. A fundamental feature of prion diseases involves a normal protein constituent of human tissue, prion protein (PrP). The chapter also talks about prevention of various other viruses, bacteria or protozoa.