16. Pluripotency and Early Cell Fate Decisions are Orchestrated by microRNAs
- Saura C. Sahu
Published Online: 6 SEP 2013
Copyright © 2014 John Wiley & Sons, Ltd.
microRNAs in Toxicology and Medicine
How to Cite
Jung, M. and Schroeder, I. S. (2013) Pluripotency and Early Cell Fate Decisions are Orchestrated by microRNAs, in microRNAs in Toxicology and Medicine (ed S. C. Sahu), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9781118695999.ch16
Division of Toxicology, Center for Food Safety and Applied Nutrition, Food and Drug Administration, USA
- Published Online: 6 SEP 2013
- Published Print: 7 OCT 2013
Print ISBN: 9781118401613
Online ISBN: 9781118695999
- cell fate decisions;
- embryonic stem (ES) cell identity;
- induced pluripotent stem (iPS) cells;
The use of induced pluripotent stem (iPS) cells expand the opportunities to study diseases, as patient-derived iPS cells help to analyze the disease process at a cellular level allowing accessing the influence of factors such as genetic predisposition. In both, the maintenance of pluripotency and in the differentiation of pluripotent stem cells to cells of various tissues, microRNAs (miRs), small RNAs of approximately 22 nucleotides (nts) in length, play an important role. This chapter describes biogenesis and function of miRs. It discusses how they influence embryonic stem (ES) cell identity, induced pluripotency, and cell fate decisions. Human and mouse miRs are shown in relation to signaling pathways for the induction of pluripotency in somatic cells, for the maintenance of pluripotent ES cells, and for the early differentiation of pluripotentstem cells. MicroRNAs are involved in silencing of the ES cell program by the repression of pluripotency-associated genes during induction of differentiation.