2. Environmental Toxicants and Perturbation of miRNA Signaling

  1. Saura C. Sahu
  1. Kathryn A. Bailey and
  2. Rebecca C. Fry

Published Online: 6 SEP 2013

DOI: 10.1002/9781118695999.ch2

microRNAs in Toxicology and Medicine

microRNAs in Toxicology and Medicine

How to Cite

Bailey, K. A. and Fry, R. C. (2013) Environmental Toxicants and Perturbation of miRNA Signaling, in microRNAs in Toxicology and Medicine (ed S. C. Sahu), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9781118695999.ch2

Editor Information

  1. Division of Toxicology, Center for Food Safety and Applied Nutrition, Food and Drug Administration, USA

Author Information

  1. Department of Environmental Sciences and Engineering, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, USA

Publication History

  1. Published Online: 6 SEP 2013
  2. Published Print: 7 OCT 2013

ISBN Information

Print ISBN: 9781118401613

Online ISBN: 9781118695999

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Keywords:

  • disease development;
  • environmental toxicants;
  • miRNA dysregulation;
  • miRNA expression;
  • perturbation;
  • toxic effects

Summary

This chapter highlights various aspects of miRNAs, including their description, history, biological significance, expression and processing, and their interactions with their mRNA targets. It discusses the current state of knowledge regarding the effect of various environmental toxicants on miRNA profiles. A comprehensive literature search revealed that for many environmental toxicants, there is no information or very little information available in terms of their effects on miRNA expression. The chemicals are divided into four major classes and are notable for their toxic effects, known or suspected roles in human disease development, and potential for widespread exposure. The chapter includes studies that represent primary areas of research examining miRNA alterations associated with each toxicant. It focuses on those studies that provide insight into the mechanisms involved in miRNA dysregulation and how such perturbation may lead to disease development.