21. Body Fluid microRNAs as Toxicological Biomarkers
- Saura C. Sahu
Published Online: 6 SEP 2013
Copyright © 2014 John Wiley & Sons, Ltd.
microRNAs in Toxicology and Medicine
How to Cite
Wang, Z. and Yang, C. (2013) Body Fluid microRNAs as Toxicological Biomarkers, in microRNAs in Toxicology and Medicine (ed S. C. Sahu), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9781118695999.ch21
Division of Toxicology, Center for Food Safety and Applied Nutrition, Food and Drug Administration, USA
- Published Online: 6 SEP 2013
- Published Print: 7 OCT 2013
Print ISBN: 9781118401613
Online ISBN: 9781118695999
- body fluid miRNAs;
- miRNA expressions;
- toxicant exposures
This chapter discusses the history, biogenesis and functions for microRNAs (miRNAs). The miRNA expression profiles of human cancer tissues have been shown to be very informative, reflecting signatures associated with cancer diagnosis, progression, response to treatment and final prognosis. These findings highlight the potential of profiling miRNA expressions as biomarkers for cancer diagnosis. Due to the exceptional stability and non-invasive nature of body fluid miRNAs, a subsequent large numbers of studies have now shown that body fluid miRNAs could be used as promising novel biomarkers for the detection of cancer and other diseases, and for assessing early responses to toxicant or drug exposures. The potential usefulness of serum miRNAs as diagnostic biomarkers for drug- and liver transplantation caused liver injuries has been explored in recent human studies. Identifying reliable and non-invasive biomarkers for early diagnosis of heart injuries remains one of the major challenges in cardiovascular research.