5. microRNAs and Inflammation

  1. Saura C. Sahu
  1. Yan Huang,
  2. Samir N. Ghadiali and
  3. S. Patrick Nana-Sinkam

Published Online: 6 SEP 2013

DOI: 10.1002/9781118695999.ch5

microRNAs in Toxicology and Medicine

microRNAs in Toxicology and Medicine

How to Cite

Huang, Y., Ghadiali, S. N. and Nana-Sinkam, S. P. (2013) microRNAs and Inflammation, in microRNAs in Toxicology and Medicine (ed S. C. Sahu), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9781118695999.ch5

Editor Information

  1. Division of Toxicology, Center for Food Safety and Applied Nutrition, Food and Drug Administration, USA

Author Information

  1. The Ohio State University, Dorothy M. Davis Heart and Lung Research Institute, USA

Publication History

  1. Published Online: 6 SEP 2013
  2. Published Print: 7 OCT 2013

ISBN Information

Print ISBN: 9781118401613

Online ISBN: 9781118695999

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Keywords:

  • immune system;
  • inflammation;
  • inflammatory diseases;
  • microRNAs (miRNAs)

Summary

MicroRNAs (miRNAs) have emerged as fine-tune regulators of the immune system modulating both acquired and innate immune responses. The recognition of a role for miRNAs in inflammation has in turn furthered the understanding of the molecular pathogenesis of diseases. However, due to the inherent complexities of miRNA regulation on their targets, the authors are still at an early stage of exploring the functional roles of miRNAs in inflammatory diseases. The regulation of miRNAs can be cell- or tissue-specific. It is likely that multiple miRNAs, rather than a single miRNA, synergistically act together to regulate gene expression and thus biological networks in response to stress. Therefore, a better understanding about how miRNAs regulate gene networks in general may provide insights into novel regulatory mechanisms. miRNAs are changing the way we think about the development of the immune system and the regulation of immune functions and inflammatory responses.