11. Further Topics
Published Online: 11 OCT 2013
Copyright © 2014 Bee Choo Tai and David Machin.
Regression Methods for Medical Research
How to Cite
Tai, B. C. and Machin, D. (2013) Further Topics, in Regression Methods for Medical Research, John Wiley & Sons Ltd, Oxford. doi: 10.1002/9781118721957.ch11
- Published Online: 11 OCT 2013
- Published Print: 29 NOV 2013
Print ISBN: 9781444331448
Online ISBN: 9781118721957
- fractional polynomials;
- model structure;
This chapter describes some applications of fractional polynomials, which allow more flexible regression models to be considered. It considers circumstances in which y, the endpoint variable, itself is also assessed before randomization. In certain situations, the method of delivery of the intervention prevents it being given on an individual participant basis, rather it can only be delivered to collections of individuals. In the designs the associated auto-correlation implies that the next recorded observation from an individual can be predicted to some extent by previous values. Although we have used a continuous measure as the endpoint in our illustration of multi-level modeling, the methods can be adapted to settings with binary, ordered categorical, count or survival time endpoints.