7. Strategies to Switch Fluorescence with Photochromic Oxazines

  1. Mogens Brøndsted Nielsen
  1. Erhan Deniz,
  2. Janet Cusido,
  3. Massimiliano Tomasulo,
  4. Mutlu Battal,
  5. Ibrahim Yildiz,
  6. Marco Petriella,
  7. Mariano L. Bossi,
  8. Salvatore Sortino and
  9. Françisco M. Raymo

Published Online: 25 OCT 2013

DOI: 10.1002/9781118736449.ch7

Organic Synthesis and Molecular Engineering

Organic Synthesis and Molecular Engineering

How to Cite

Deniz, E., Cusido, J., Tomasulo, M., Battal, M., Yildiz, I., Petriella, M., Bossi, M. L., Sortino, S. and Raymo, F. M. (2013) Strategies to Switch Fluorescence with Photochromic Oxazines, in Organic Synthesis and Molecular Engineering (ed M. B. Nielsen), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118736449.ch7

Editor Information

  1. Department of Chemistry, University of Copenhagen, Copenhagen, Denmark

Publication History

  1. Published Online: 25 OCT 2013
  2. Published Print: 18 NOV 2013

ISBN Information

Print ISBN: 9781118150924

Online ISBN: 9781118736449



  • fluorescence activation;
  • fluorophore-oxazine dyads;
  • photochromic oxazines;
  • subdiffraction resolution


Photochromic compounds switch reversibly between states with distinct absorption properties in the visible region under the influence of optical stimulation. This chapter deals with switching of fluorescence with photochromic oxazines. It describes the design and synthesis of fluorophore-oxazine dyads, and discusses fluorescence activation with fluorophore-oxazine dyads. The unique combination of photochemical and photophysical properties associated with the fluorophore-photochrome dyads entrapped within the micelles offers the opportunity to overcome diffraction and resolve structural features at the nanoscale. Our strategies for fluorescence activation with photochromic oxazines can eventually lead to the realization of an entire family of photoswitchable fluorophores for the visualization of biological samples with subdiffraction resolution.