3. The Immunological Basis of Non-IgE-Mediated Reactions

  1. Dean D. Metcalfe MD3,
  2. Hugh A. Sampson MD4,
  3. Ronald A. Simon MD5,6 and
  4. Gideon Lack MBBCh (Oxon), MA (Oxon), FRCPCH7
  1. Ashraf Uzzaman1 and
  2. Hirsh D. Komarow2

Published Online: 24 FEB 2014

DOI: 10.1002/9781118744185.ch3

Food Allergy: Adverse Reactions to Foods and Food Additives, Fifth Edition

Food Allergy: Adverse Reactions to Foods and Food Additives, Fifth Edition

How to Cite

Uzzaman, A. and Komarow, H. D. (2013) The Immunological Basis of Non-IgE-Mediated Reactions, in Food Allergy: Adverse Reactions to Foods and Food Additives, Fifth Edition (eds D. D. Metcalfe, H. A. Sampson, R. A. Simon and G. Lack), John Wiley & Sons Ltd, Chichester, UK. doi: 10.1002/9781118744185.ch3

Editor Information

  1. 3

    Chief, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA

  2. 4

    Kurt Hirschhorn Professor of Pediatrics, Dean for Translational Biomedical Sciences, Director, Jaffe Food Allergy Institute Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA

  3. 5

    Head, Division of Allergy, Asthma and Immunology, Scripps Clinic, San Diego, CA, USA

  4. 6

    Adjunct Professor, Department of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, CA, USA

  5. 7

    Professor of Paediatric Allergy, King's College London Clinical Lead for Allergy Service, Guy's and St Thomas' NHS Foundation Trust, St Thomas' Hospital, London, UK

Author Information

  1. 1

    Saline Allergy Asthma Sinus Specialists, Saline, MI, USA

  2. 2

    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA

Publication History

  1. Published Online: 24 FEB 2014
  2. Published Print: 10 DEC 2013

ISBN Information

Print ISBN: 9780470672556

Online ISBN: 9781118744185

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Keywords:

  • food allergy;
  • non-IgE mediated;
  • eosinophilic gastrointestinal disease;
  • food protein-induced enteropathy;
  • mucosal immunity;
  • celiac disease;
  • oral tolerance

Summary

This chapter provides a comprehensive overview of the immunological basis of non-IgE-mediated as well as mixed IgE-mediated mechanisms of food allergy. It details factors that affect the development of food allergy, the immunologic anatomy and defense mechanisms of the gut, which avert the development of food allergy, the processing of enteral food antigens and their presentation to immune competent cells of the gastrointestinal tract, and the effector cells and inflammatory mediators critical to the propagation and consequences of abnormal reactions to foods.