5. Polymeric Nanoparticles

  1. Rebecca A. Bader3 and
  2. David A. Putnam4
  1. Andrew L. Vasilakes1,
  2. Thomas D. Dziubla1 and
  3. Paritosh P. Wattamwar2

Published Online: 17 JAN 2014

DOI: 10.1002/9781118747896.ch5

Engineering Polymer Systems for Improved Drug Delivery

Engineering Polymer Systems for Improved Drug Delivery

How to Cite

Vasilakes, A. L., Dziubla, T. D. and Wattamwar, P. P. (2013) Polymeric Nanoparticles, in Engineering Polymer Systems for Improved Drug Delivery (eds R. A. Bader and D. A. Putnam), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118747896.ch5

Editor Information

  1. 3

    Syracuse Biomaterials Institute, Syracuse University, Syracuse, NY, USA

  2. 4

    Department of Biomedical Engineering, Cornell University, Ithaca, NY, USA

Author Information

  1. 1

    Department of Chemical and Materials Engineering, University of Kentucky, Lexington, KY, USA

  2. 2

    Teva Pharmaceutical Industries Ltd., West Chester, PA, USA

Publication History

  1. Published Online: 17 JAN 2014
  2. Published Print: 27 DEC 2013

ISBN Information

Print ISBN: 9781118098479

Online ISBN: 9781118747896

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Keywords:

  • biodistribution;
  • nanoparticle drug delivery;
  • PNP design;
  • polymeric nanoparticles (PNPs);
  • polymers;
  • targeting techniques

Summary

The central goal of drug delivery is the optimization of the pharmacokinetics/pharmocodynamics (PK/PD) for a specific medicinal application. One class of nanoparticles that provides the greatest flexibility in tuning, and hence the largest class of nanoparticle studied, is polymeric nanoparticles (PNPs). This chapter discusses the different types of PNPs and routes of targeting. It explains biodistribution and how to measure the different pertinent effects PNPs exhibit. Given the extensive array of chemistries and mechanical properties available in polymers, there is conceptually no limit to the forms and designs of PNPs that can be made. The chapter summarizes the approaches that have been developed, and discusses their relative advantages and disadvantages. It reviews formulation techniques for PNPs. These techniques can be combined and interchanged to form a variety of PNP structures. The chapter exemplifies the different possibilities of using different configurations of PNPs with different compositions and targeting techniques.