6. Evaluation and Medical Management of Sleep-Disordered Breathing

  1. Douglas B. Kirsch MD, FAASM4,5
  1. Mihaela H. Bazalakova MD, PhD1,2 and
  2. Lawrence J. Epstein MD1,3

Published Online: 11 OCT 2013

DOI: 10.1002/9781118764152.ch6

Sleep Medicine in Neurology

Sleep Medicine in Neurology

How to Cite

Bazalakova, M. H. and Epstein, L. J. (2013) Evaluation and Medical Management of Sleep-Disordered Breathing, in Sleep Medicine in Neurology (ed D. B. Kirsch), John Wiley & Sons, Oxford. doi: 10.1002/9781118764152.ch6

Editor Information

  1. 4

    Harvard Medical School, Boston, MA, USA

  2. 5

    Division of Sleep Neurology, Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA

Author Information

  1. 1

    Division of Sleep Medicine, Department of Medicine, Brigham and Women's Hospital, USA

  2. 2

    Department of Neurology, Massachusetts General Hospital, USA

  3. 3

    Harvard Medical School, USA

Publication History

  1. Published Online: 11 OCT 2013
  2. Published Print: 7 OCT 2013

ISBN Information

Print ISBN: 9781444335514

Online ISBN: 9781118764152



  • narcolepsy;
  • excessive daytime sleepiness;
  • hypersomnia;
  • cataplexy;
  • sleep paralysis;
  • hypnagogic hallucinations.


Excessive sleepiness is one of the major symptoms in Narcolepsy. Narcolepsy is one of the most common hypersomnias of central nervous system origin. It is defined by the major symptoms of: hypersomnia, cataplexy, hypnagogic hallucinations, and sleep paralysis. Excessive daytime sleepiness is present in all patients. Cataplexy is pathognomonic for narcolepsy. Diagnostic evaluation usually includes an overnight polysomnogram followed by a next day multiple sleep latency test (MSLT). Treatment requires a multimodal approach with the use of wake promoting agents and REM-suppressant medications.