16. Bioorganometallic Chemistry

  1. Robert H. Crabtree

Published Online: 28 MAR 2014

DOI: 10.1002/9781118788301.ch16

The Organometallic Chemistry of the Transition Metals, 6

The Organometallic Chemistry of the Transition Metals, 6

How to Cite

Crabtree, R. H. (ed) (2014) Bioorganometallic Chemistry, in The Organometallic Chemistry of the Transition Metals, 6, John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118788301.ch16

Editor Information

  1. Yale University, New Haven, Connecticut

Publication History

  1. Published Online: 28 MAR 2014
  2. Published Print: 21 APR 2014

ISBN Information

Print ISBN: 9781118138076

Online ISBN: 9781118788301

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Keywords:

  • proteins;
  • protein structure;
  • metalloenzymes;
  • modeling;
  • molecular recognition;
  • coenzymes;
  • mutase reaction;
  • bioalkylation;
  • nitrogenase;
  • Fe—S clusters

Summary

A discussion of basic biochemistry is followed by a section on coenzyme B12, its mechanism of action, and how model compounds helped in this project. Nitrogen fixation follows, with emphasis on the enzyme, but also mentioning some model chemistry and the topic of dinitrogen complexes. Nickel enzymes are discussed, particularly the organometallic ones that have CO and CN ligands in the active site cluster. Biomedical and biocatalytic applications follow with a discussion of organometallic drugs.