10. MicroRNA and Inflammation-Related Cancer

  1. Yusuke Hiraku1,
  2. Shosuke Kawanishi2 and
  3. Hiroshi Ohshima3
  1. Zhaojian Gong,
  2. Zhaoyang Zeng,
  3. Pranab Behari Mazumder,
  4. Jian Ma,
  5. Ming Zhou,
  6. Xiayu Li,
  7. Xiaoling Li,
  8. Wei Xiong,
  9. Yong Li and
  10. Guiyuan Li

Published Online: 4 APR 2014

DOI: 10.1002/9781118826621.ch10

Cancer and Inflammation Mechanisms: Chemical, Biological, and Clinical Aspects

Cancer and Inflammation Mechanisms: Chemical, Biological, and Clinical Aspects

How to Cite

Gong, Z., Zeng, Z., Mazumder, P. B., Ma, J., Zhou, M., Li, X., Li, X., Xiong, W., Li, Y. and Li, G. (2014) MicroRNA and Inflammation-Related Cancer, in Cancer and Inflammation Mechanisms: Chemical, Biological, and Clinical Aspects (eds Y. Hiraku, S. Kawanishi and H. Ohshima), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118826621.ch10

Editor Information

  1. 1

    Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Tsu, Mie, Japan

  2. 2

    Faculty of Pharmaceutical Sciences, Suzuka University of Medical Science, Suzuka, Mie, Japan

  3. 3

    Department of Nutritional and Environmental Sciences, Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, Shizuoka, Japan

Publication History

  1. Published Online: 4 APR 2014
  2. Published Print: 4 APR 2014

ISBN Information

Print ISBN: 9781118160305

Online ISBN: 9781118826621

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Keywords:

  • inflammation;
  • inflammation-induced carcinogenesis;
  • inflammation-related cancer;
  • metastasis;
  • microRNA;
  • single-nucleotide polymorphisms (SNPs)

Summary

Inflammation has been recognized as a hallmark of cancer. Substantial evidence supports the finding that microRNAs not only play important roles in tumor initiation but also participate in the invasion and metastasis of numerous inflammation-related cancers. Investigation of the interrelation between miRNAs and inflammation-related cancers may provide novel preventive, diagnostic, and therapeutic strategies for cancers. Inflammation plays a critical role in carcinogenesis, and an inflammatory microenvironment is considered an essential component of almost all solid tumors. Metastasis is a critical aspect of carcinogenesis, since most cancer mortality is associated with metastatic tumors rather than the primary tumor. An increasing number of pro- and anti-metastatic miRNAs have been reported to regulate the metastasis of many inflammation-related cancers. Single-nucleotide polymorphisms (SNPs) are the most common variations in DNA sequences. These miRNA-related SNPs play a substantial role in much inflammation related cancer development, including hepatocellular carcinoma (HCC), lung cancer, and colorectal cancer.