3. Environmental Chemicals Targeting Estrogen Signaling Pathways
Published Online: 23 MAY 2014
Copyright © 2014 John Wiley & Sons, Inc.
Endocrine Disruptors in the Environment
How to Cite
K. Khetan, S. (2014) Environmental Chemicals Targeting Estrogen Signaling Pathways, in Endocrine Disruptors in the Environment, John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118891094.ch3
- Published Online: 23 MAY 2014
- Published Print: 9 JUN 2014
Print ISBN: 9781118852934
Online ISBN: 9781118891094
- estrogen disruptors;
- steroidal estrogens;
- estrogenic chemicals;
- sun screens
Estrogen mimetic environmental chemicals are exogenous, natural and synthetic chemicals that alter the functions of the endocrine system by mimicking or blocking endogenous estrogen through inappropriate estrogen receptor (ER) signaling. This causes abnormal development of male and female reproductive tracts, feminization of males, lowered sperm counts, disruption to reproductive cycling, and reduced fertility and behavioral changes. Key players in the environmental estrogen story are the putative estrogenic chemicals, such as synthetic estrogen DES, the organochlorine pesticides such as DDT, polychlorinated biphenyls, plasticizer BPA, nonyl and octylphenol and heavy metals arsenic and cadmium.