3. Environmental Chemicals Targeting Estrogen Signaling Pathways

  1. Sushil K. Khetan

Published Online: 23 MAY 2014

DOI: 10.1002/9781118891094.ch3

Endocrine Disruptors in the Environment

Endocrine Disruptors in the Environment

How to Cite

K. Khetan, S. (2014) Environmental Chemicals Targeting Estrogen Signaling Pathways, in Endocrine Disruptors in the Environment, John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118891094.ch3

Publication History

  1. Published Online: 23 MAY 2014
  2. Published Print: 9 JUN 2014

ISBN Information

Print ISBN: 9781118852934

Online ISBN: 9781118891094

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Keywords:

  • alkylphenols;
  • estrogen disruptors;
  • steroidal estrogens;
  • estrogenic chemicals;
  • metalloestrogens;
  • organochlorines;
  • parabens;
  • sun screens

Summary

Estrogen mimetic environmental chemicals are exogenous, natural and synthetic chemicals that alter the functions of the endocrine system by mimicking or blocking endogenous estrogen through inappropriate estrogen receptor (ER) signaling. This causes abnormal development of male and female reproductive tracts, feminization of males, lowered sperm counts, disruption to reproductive cycling, and reduced fertility and behavioral changes. Key players in the environmental estrogen story are the putative estrogenic chemicals, such as synthetic estrogen DES, the organochlorine pesticides such as DDT, polychlorinated biphenyls, plasticizer BPA, nonyl and octylphenol and heavy metals arsenic and cadmium.