15. Neuropsychological Sequelae of Childhood Cancer

  1. Shulamith Kreitler3,4,5,
  2. Myriam Weyl Ben-Arush6,7 and
  3. Andrés Martin8,9
  1. Matthew C. Hocking1 and
  2. Melissa A. Alderfer2

Published Online: 1 JUL 2012

DOI: 10.1002/9781119941033.ch15

Pediatric Psycho-Oncology: Psychosocial Aspects and Clinical Interventions, Second Edition

Pediatric Psycho-Oncology: Psychosocial Aspects and Clinical Interventions, Second Edition

How to Cite

Hocking, M. C. and Alderfer, M. A. (2012) Neuropsychological Sequelae of Childhood Cancer, in Pediatric Psycho-Oncology: Psychosocial Aspects and Clinical Interventions, Second Edition (eds S. Kreitler, M. W. Ben-Arush and A. Martin), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9781119941033.ch15

Editor Information

  1. 3

    School of Psychological Sciences, Tel-Aviv University, Israel

  2. 4

    Psychooncology Research Center, Sheba Medical Center, Tel Hashomer, Israel

  3. 5

    Faculty of Social Welfare and Health Sciences, University of Haifa, Israel

  4. 6

    Department of Pediatric Hematology Oncology, Meyer Children's Hospital, Israel

  5. 7

    Meyer Children's Hospital, Rambam Health Care Campus, Technion Israel-Institute of Technology, the Bruce Rappaport Faculty of Medicine, Haifa, Israel

  6. 8

    Child Study Center, Yale University School of Medicine, USA

  7. 9

    Smilow Cancer Hospital at Yale-New Haven, New Haven, CT, USA

Author Information

  1. 1

    Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA

  2. 2

    The Children's Hospital of Philadelphia and Perelman School of Medicine, The University of Pennsylvania, Philadelphia, PA, USA

Publication History

  1. Published Online: 1 JUL 2012
  2. Published Print: 27 JUL 2012

ISBN Information

Print ISBN: 9781119998839

Online ISBN: 9781119941033



  • acute lymphoblastic leukemia (ALL);
  • brain tumor;
  • neurocognitive sequelae;
  • pediatric cancer;
  • survivorship


Children treated for acute lymphoblastic leukemia and malignancies of the central nervous system often experience neurocognitive sequelae secondary to their disease and treatment. This chapter provides an overview of the types and causes of neurocognitive late effects and the known risk factors for poorer outcomes, including age at diagnosis and the use of cranial radiation. Current standards of clinical care for these survivors are presented and the state of the research on interventions for these neurocognitive sequelae is summarized. Future directions for research and clinical care are offered in order to further efforts directed at identifying those at greatest risk for poor outcomes and preventing and remediating neurocognitive sequelae.