12. Neurocognitive Angle: The Search for Endophenotypes
- Joseph Zohar2,3
Published Online: 12 JUN 2012
DOI: 10.1002/9781119941125.ch12
Copyright © 2012 John Wiley & Sons, Ltd
Book Title
Obsessive-Compulsive Disorder: Current Science and Clinical Practice
Additional Information
How to Cite
Chamberlain, S. R. and Menzies, L. (2012) Neurocognitive Angle: The Search for Endophenotypes, in Obsessive-Compulsive Disorder: Current Science and Clinical Practice (ed J. Zohar), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9781119941125.ch12
Editor Information
- 2
Psychiatry Department A, Division of Psychiatry, Chaim Sheba Medical Center, Tel Hashomer, Israel
- 3
Tel Aviv University, Tel Aviv, Israel
Publication History
- Published Online: 12 JUN 2012
- Published Print: 13 MAR 2012
ISBN Information
Print ISBN: 9780470711255
Online ISBN: 9781119941125
- Summary
- Chapter
- References
Keywords:
- neurocognitive angle, the search for endophenotypes;
- OCD and brain neural circuitry, the ‘neurocognitive angle’;
- translational medicine in cognitive, and neurotransmitter systems;
- neurocognitive tests on inhibitory control, and cognitive flexibility;
- endophenotype, heritable risk factor, with epigenetic, pleiotropic role;
- endophenotyping, in multiple nonpsychiatric contexts;
- endophenotype strategy in OCD, its machinations with genes;
- hierarchical disease model, steps between genotype, phenotype;
- OCD and confirming heritability, than just the familial;
- endophenotypes, and the overlap, OCD and related Axis-I disorders
Summary
This chapter contains sections titled:
Introduction
Heritability of OCD
The concept of an endophenotype
Applying the endophenotype construct to OCD
Domains of interest in hierarchical modelling of OCD
Searching for endophenotypes of OCD
Summary
Acknowledgements and disclosures
References