12. Neurocognitive Angle: The Search for Endophenotypes

  1. Joseph Zohar2,3
  1. Samuel R. Chamberlain and
  2. Lara Menzies

Published Online: 12 JUN 2012

DOI: 10.1002/9781119941125.ch12

Obsessive-Compulsive Disorder: Current Science and Clinical Practice

Obsessive-Compulsive Disorder: Current Science and Clinical Practice

How to Cite

Chamberlain, S. R. and Menzies, L. (2012) Neurocognitive Angle: The Search for Endophenotypes, in Obsessive-Compulsive Disorder: Current Science and Clinical Practice (ed J. Zohar), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9781119941125.ch12

Editor Information

  1. 2

    Psychiatry Department A, Division of Psychiatry, Chaim Sheba Medical Center, Tel Hashomer, Israel

  2. 3

    Tel Aviv University, Tel Aviv, Israel

Author Information

  1. Department of Psychiatry, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK

Publication History

  1. Published Online: 12 JUN 2012
  2. Published Print: 13 MAR 2012

ISBN Information

Print ISBN: 9780470711255

Online ISBN: 9781119941125

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Keywords:

  • neurocognitive angle, the search for endophenotypes;
  • OCD and brain neural circuitry, the ‘neurocognitive angle’;
  • translational medicine in cognitive, and neurotransmitter systems;
  • neurocognitive tests on inhibitory control, and cognitive flexibility;
  • endophenotype, heritable risk factor, with epigenetic, pleiotropic role;
  • endophenotyping, in multiple nonpsychiatric contexts;
  • endophenotype strategy in OCD, its machinations with genes;
  • hierarchical disease model, steps between genotype, phenotype;
  • OCD and confirming heritability, than just the familial;
  • endophenotypes, and the overlap, OCD and related Axis-I disorders

Summary

This chapter contains sections titled:

  • Introduction

  • Heritability of OCD

  • The concept of an endophenotype

  • Applying the endophenotype construct to OCD

  • Domains of interest in hierarchical modelling of OCD

  • Searching for endophenotypes of OCD

  • Summary

  • Acknowledgements and disclosures

  • References