2. Pharmacotherapy of Obsessive-Compulsive Disorder

  1. Joseph Zohar3,4
  1. Eric H. Decloedt1 and
  2. Dan J. Stein2

Published Online: 12 JUN 2012

DOI: 10.1002/9781119941125.ch2

Obsessive-Compulsive Disorder: Current Science and Clinical Practice

Obsessive-Compulsive Disorder: Current Science and Clinical Practice

How to Cite

Decloedt, E. H. and Stein, D. J. (2012) Pharmacotherapy of Obsessive-Compulsive Disorder, in Obsessive-Compulsive Disorder: Current Science and Clinical Practice (ed J. Zohar), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9781119941125.ch2

Editor Information

  1. 3

    Psychiatry Department A, Division of Psychiatry, Chaim Sheba Medical Center, Tel Hashomer, Israel

  2. 4

    Tel Aviv University, Tel Aviv, Israel

Author Information

  1. 1

    Department of Medicine, Division of Clinical Pharmacology, University of Cape Town, Cape Town, South Africa

  2. 2

    Department of Psychiatry, University of Cape Town, Cape Town, South Africa

Publication History

  1. Published Online: 12 JUN 2012
  2. Published Print: 13 MAR 2012

ISBN Information

Print ISBN: 9780470711255

Online ISBN: 9781119941125

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Keywords:

  • pharmacotherapy of obsessive-compulsive disorder;
  • OCD patients in pharmacological, measurement using scales;
  • drug pharmacokinetics in children, differing from adults;
  • fluoxetine use in childhood OCD;
  • meta-analysis, comparing efficacy of agents in OCD;
  • clomipramine, serotonin reuptake inhibitors in OCD;
  • switching SSRIs, in treatment-resistant OCD;
  • treatment-refractory OCD, clinical issue;
  • added cognitive behavioural psychotherapy

Summary

This chapter contains sections titled:

  • Introduction

  • Placebo-controlled studies of clomipramine

  • Placebo-controlled studies of fluvoxamine

  • Placebo-controlled studies of fluoxetine

  • Placebo-controlled studies of paroxetine

  • Placebo-controlled studies of sertraline

  • Placebo-controlled studies of citalopram/escitalopram

  • Placebo-controlled studies of venlafaxine

  • Improving early response in OCD

  • Special populations: children

  • Clomipramine

  • Meta-analyses

  • Tolerability of clomipramine and serotonin reuptake inhibitors

  • Optimal dose of treatment

  • Duration of treatment

  • Refractory OCD

  • Future therapeutic options

  • Conclusion

  • References