5. Approaches to Treatment Resistance

  1. Joseph Zohar4,5
  1. Stefano Pallanti1,2,3,
  2. Giacomo Grassi2 and
  3. Andrea Cantisani2

Published Online: 12 JUN 2012

DOI: 10.1002/9781119941125.ch5

Obsessive-Compulsive Disorder: Current Science and Clinical Practice

Obsessive-Compulsive Disorder: Current Science and Clinical Practice

How to Cite

Pallanti, S., Grassi, G. and Cantisani, A. (2012) Approaches to Treatment Resistance, in Obsessive-Compulsive Disorder: Current Science and Clinical Practice (ed J. Zohar), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9781119941125.ch5

Editor Information

  1. 4

    Psychiatry Department A, Division of Psychiatry, Chaim Sheba Medical Center, Tel Hashomer, Israel

  2. 5

    Tel Aviv University, Tel Aviv, Israel

Author Information

  1. 1

    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA

  2. 2

    Department of Psychiatry, University of Florence, Florence, Italy

  3. 3

    Institute of Neuroscience, Florence, Italy

Publication History

  1. Published Online: 12 JUN 2012
  2. Published Print: 13 MAR 2012

ISBN Information

Print ISBN: 9780470711255

Online ISBN: 9781119941125



  • OCD, and treatment resistance approaches;
  • treatment resistance, a feature of OCD;
  • absence of best therapeutic in OCD, disorder homogeneity lacking;
  • OCD terminological heterogeneity, compatibility with instruments/scales;
  • Y–BOCS, (CGI) scale, HRQL;
  • treatment non-response, from BD and ADHD in OCD;
  • resistant OCD, and pharmacological strategies;
  • switching, infusion, CBT, SRIs, antipsychotic, neurotransmitter glutamate;
  • OCD treatment-resistant one, patient and caregiver burden


This chapter contains sections titled:

  • Terminological problems and operational definitions

  • Pharmacological strategies in resistant OCD

  • Physical therapies

  • Family intervention

  • Conclusions and future perspectives

  • References