8. Methodological Issues for Clinical Treatment Trials in Obsessive-Compulsive Disorder

  1. Joseph Zohar3,4
  1. Samar Reghunandanan1,
  2. Naomi A. Fineberg1,2

Published Online: 12 JUN 2012

DOI: 10.1002/9781119941125.ch8

Book Title

Obsessive-Compulsive Disorder: Current Science and Clinical Practice

Obsessive-Compulsive Disorder: Current Science and Clinical Practice

Additional Information

How to Cite

Reghunandanan, S. and Fineberg, N. A. (2012) Methodological Issues for Clinical Treatment Trials in Obsessive-Compulsive Disorder, in Obsessive-Compulsive Disorder: Current Science and Clinical Practice (ed J. Zohar), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9781119941125.ch8

Editor Information

  1. 3

    Psychiatry Department A, Division of Psychiatry, Chaim Sheba Medical Center, Tel Hashomer, Israel

  2. 4

    Tel Aviv University, Tel Aviv, Israel

Author Information

  1. 1

    National OCD Treatment Service, Hertfordshire Partnership NHS Foundation Trust, Queen Elizabeth II Hospital, Welwyn Garden City, UK

  2. 2

    University of Hertfordshire, College Lane, Hatfield UK

Publication History

  1. Published Online: 12 JUN 2012
  2. Published Print: 13 MAR 2012

ISBN Information

Print ISBN: 9780470711255

Online ISBN: 9781119941125

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CHAPTER TOOLS

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Keywords:

  • research spotlights, HRQoL and disability measures in treatment response, relapse;
  • methodological strategies, for clinical treatment trials in OCD;
  • clinical biomarker identification, correlating with treatment outcomes;
  • customary design, parallel group, with crossover design, acceptable;
  • double-blind RCTs, and choice of control;
  • SSRI higher doses, clinically efficacious, associated with adverse effects;
  • placebo and ethics, in OCD disease areas;
  • nosological heterogeneity reduction, OCD subtype on treatment outcome;
  • psychiatric comorbidity, and treatment resistance in OCD;
  • OCD heterogeneity, syndromal, dimensional, subtypes and comorbidity

Summary

This chapter contains sections titled:

  • Introduction

  • Randomized controlled trials

  • The rationale of placebo

  • Recruitment criteria

  • Diagnosis

  • OCD dimensions and subtypes

  • The problem of comorbidity

  • Rating scales for OCD trials

  • Evaluating anxiety and depression in OCD

  • Measuring response and remission

  • Relapse prevention

  • Treatment-resistant OCD

  • Psychological treatment trials

  • Integrated pharmacological and psychological treatments in OCD

  • Health-related quality of life

  • Summary

  • References

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