2. Reductive Amination

  1. John Whittall11 and
  2. Peter W. Sutton12
  1. Simon Willies11,
  2. Matthew D. Truppo1,
  3. Christopher K. Savile2,
  4. Jacob M. Janey3,
  5. Jeffrey C. Moore3,
  6. Gjalt W. Huisman2,
  7. Gregory J. Hughes4,
  8. Francesco G. Mutti5,
  9. Christine S. Fuchs5,
  10. Wolfgang Kroutil5,
  11. Jennifer Hopwood11,
  12. Matthew D. Truppo1,
  13. Richard Lloyd6,
  14. Nicholas J. Turner11,
  15. Eun Young Hong7,
  16. Minho Cha7,8,
  17. Hyungdon Yun7,
  18. Byung-Gee Kim7,
  19. S. Stella9,10 and
  20. Anju Chadha9,10

Published Online: 13 MAY 2012

DOI: 10.1002/9781119943426.ch2

Practical Methods for Biocatalysis and Biotransformations 2

Practical Methods for Biocatalysis and Biotransformations 2

How to Cite

Willies, S., Truppo, M. D., Savile, C. K., Janey, J. M., Moore, J. C., Huisman, G. W., Hughes, G. J., Mutti, F. G., Fuchs, C. S., Kroutil, W., Hopwood, J., Truppo, M. D., Lloyd, R., Turner, N. J., Hong, E. Y., Cha, M., Yun, H., Kim, B.-G., Stella, S. and Chadha, A. (2012) Reductive Amination, in Practical Methods for Biocatalysis and Biotransformations 2 (eds J. Whittall and P. W. Sutton), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9781119943426.ch2

Editor Information

  1. 11

    Manchester Interdisciplinary Biocentre (MIB), The University of Manchester, 131 Princess Street, Manchester, M1 7DN, UK

  2. 12

    GlaxoSmithKline Research and Development Limited, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, UK

Author Information

  1. 1

    Merck & Co. Inc., RY800-C362, P.O. Box 2000, Rahway NJ, 07065-0900, USA

  2. 2

    Codexis, Inc., Redwood City, CA, USA

  3. 3

    Merck Research Laboratories, Merck & Co., Inc., Rahway, NJ 07065, USA

  4. 4

    Process Research, Merck Research Laboratories, Merck & Co., Inc., Rahway, NJ 07065, USA

  5. 5

    Department of Chemistry, organic and bioorganic chemistry, University of Graz, Heinrichstraße-28, 8010 Graz, Austria

  6. 6

    Dr. Reddy's, Chirotech Technology Ltd, Unit 410, Cambridge Science Park, Milton Road, Cambridge CB4 0PE, UK

  7. 7

    School of Chemical and Biological Engineering, SNU, Seoul, Republic of Korea

  8. 8

    School of Biotechnology, Yeungnam University, Gyeongsan, Gyeongbuk, Republic of Korea

  9. 9

    Laboratory of Bioorganic Chemistry, Department of Biotechnology, Indian Institute of Technology Madras, Chennai 600036, India

  10. 10

    National Center for Catalysis Research, Indian Institute of Technology Madras, Chennai 600036, India

  11. 11

    Manchester Interdisciplinary Biocentre (MIB), The University of Manchester, 131 Princess Street, Manchester, M1 7DN, UK

Publication History

  1. Published Online: 13 MAY 2012
  2. Published Print: 11 MAY 2012

ISBN Information

Print ISBN: 9781119991397

Online ISBN: 9781119943426

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Keywords:

  • reductive amination;
  • biocatalysts for chiral amine synthesis;
  • directed evolution, overcoming limitations of enzymes;
  • optically pure amines;
  • TA, PLP dependant enzymes;
  • TAs, chiral amino acids in biosystems;
  • enzymatic approach to L-HAG synthesis;
  • BcATes/AspAT coupling system, and BcATes reaction

Summary

This chapter contains sections titled:

  • ω-Transaminases – Useful Biocatalysts for Chiral Amine Synthesis

  • Preparative Scale Production of a Bulky–Bulky Chiral Amine Using an Engineered Transaminase

  • Synthesis of Optically Pure Amines Employing ω-Transaminases

  • A Fast, Sensitive Assay and Scale-Up of ω-Transaminase Catalysed Reactions

  • Asymmetric Synthesis of L-3-Hydroxyadamantylglycine Using Branched Chain Aminotransferase

  • Asymmetric Reduction of Aryl Imines Using Candida parapsilosis ATCC 7330