4. Industrial Carbonyl Reduction

  1. John Whittall7 and
  2. Peter W. Sutton8
  1. David P. Mangan1,
  2. Thomas S. Moody1,
  3. Owen Gooding2,
  4. Gjalt W. Huisman3,
  5. Carlos A. Martinez4,
  6. Adam Smogowicz4,
  7. Jeremy S. Steflik4,
  8. Maria S. Brown4,
  9. Katarina S. Midelfort4,
  10. Michael P. Burns4,
  11. John W. Wong5 and
  12. Jack Liang6

Published Online: 13 MAY 2012

DOI: 10.1002/9781119943426.ch4

Practical Methods for Biocatalysis and Biotransformations 2

Practical Methods for Biocatalysis and Biotransformations 2

How to Cite

Mangan, D. P., Moody, T. S., Gooding, O., Huisman, G. W., Martinez, C. A., Smogowicz, A., Steflik, J. S., Brown, M. S., Midelfort, K. S., Burns, M. P., Wong, J. W. and Liang, J. (2012) Industrial Carbonyl Reduction, in Practical Methods for Biocatalysis and Biotransformations 2 (eds J. Whittall and P. W. Sutton), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9781119943426.ch4

Editor Information

  1. 7

    Manchester Interdisciplinary Biocentre (MIB), The University of Manchester, 131 Princess Street, Manchester, M1 7DN, UK

  2. 8

    GlaxoSmithKline Research and Development Limited, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, UK

Author Information

  1. 1

    Almac Sciences, Almac House, 20 Seagoe Industrial Estate, Craigavon, BT63 5QD, UK

  2. 2

    Codexis Inc., Redwood City, California, USA

  3. 3

    Codexis Inc., 515 Galveston Drive, Redwood City, CA 94063, USA

  4. 4

    Biocatalysis Center of Emphasis, Chemical R&D, Pharmaceutical Sciences, Pfizer Worldwide Research & Development, Pfizer, Groton, CT, USA

  5. 5

    Pfizer Chemical Research & Development, Office 118E/360B, MS 8118A-2109, Eastern Point Road, Groton, CT 06340, USA

  6. 6

    Codexis Inc., Redwood City, CA, USA

Publication History

  1. Published Online: 13 MAY 2012
  2. Published Print: 11 MAY 2012

ISBN Information

Print ISBN: 9781119991397

Online ISBN: 9781119943426

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Keywords:

  • industrial carbonyl reduction;
  • chiral secondary alcohols, in pharmaceutical synthetic routes;
  • large scale chiral synthesis;
  • bioreduction, using immobilized carbonyl reductase;
  • CRED technology;
  • R2MP from racemic 2-methylvaleraldehyde;
  • enzymatic manufacture, for Montelukast chiral alcohol

Summary

This chapter contains sections titled:

  • Bioreduction Using Immobilized Carbonyl Reductase Technology

  • Preparative Ketoreductase-Catalyzed Kinetic Resolution of a Racemic Aldehyde

  • Enzymatic Reduction of 2,6-dichloro-3-fluoro-acetophenone to Produce (S)-1-(2,6-dichloro-3-fluorophenyl)ethanol

  • Preparative Scale Production of Poorly Soluble Chiral Alcohol Intermediate for Montelukast