14. Analysis of Interaction for Identifying Causal Mechanisms

  1. Carlo Berzuini,
  2. Philip Dawid and
  3. Luisa Bernardinelli
  1. Carlo Berzuini2,
  2. Philip Dawid2,
  3. Hu Zhang1 and
  4. Miles Parkes1

Published Online: 25 JUN 2012

DOI: 10.1002/9781119945710.ch14

Causality: Statistical Perspectives and Applications

Causality: Statistical Perspectives and Applications

How to Cite

Berzuini, C., Dawid, P., Zhang, H. and Parkes, M. (2012) Analysis of Interaction for Identifying Causal Mechanisms, in Causality: Statistical Perspectives and Applications (eds C. Berzuini, P. Dawid and L. Bernardinelli), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9781119945710.ch14

Editor Information

  1. Statistical Laboratory, Centre for Mathematical Sciences, University of Cambridge, Cambridge, UK

Author Information

  1. 1

    Department of Gastroenterology, Addenbrookes Hospital, Cambridge, UK

  2. 2

    Statistical Laboratory, Centre for Mathematical Sciences, University of Cambridge, Cambridge, UK

Publication History

  1. Published Online: 25 JUN 2012
  2. Published Print: 13 JUL 2012

Book Series:

  1. Wiley Series in Probability and Statistics

Book Series Editors:

  1. Walter A. Shewhart and
  2. Samuel S. Wilks

ISBN Information

Print ISBN: 9780470665565

Online ISBN: 9781119945710

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Keywords:

  • causal mechanism identification, analysis of interaction;
  • EOA, as ‘What is the effect of causal action X?’;
  • Tyler Vander Weele's mechanistic interaction, in epidemiology;
  • ‘mechanism’ parts and operations, for specific tasks;
  • statistical versus mechanistic interaction;
  • mechanistic interaction and epistasis in genetic epidemiology;
  • ‘no confounding’ requirements, between counterfactuals;
  • Crohn's disease data, mechanistic interaction and risk, superadditivity;
  • risk and superadditivity conditions, collapsibility, alternative approaches

Summary

This chapter contains sections titled:

  • Introduction

  • What is a mechanism?

  • Statistical versus mechanistic interaction

  • Illustrative example

  • Mechanistic interaction defined

  • Epistasis

  • Excess risk and superadditivity

  • Conditions under which excess risk and superadditivity indicate the presence of mechanistic interaction

  • Collapsibility

  • Back to the illustrative study

  • Alternative approaches

  • Discussion

  • Ethics statement

  • Financial disclosure

  • References