20. Evaluation of Potential Mediators in Randomised Trials of Complex Interventions (Psychotherapies)

  1. Carlo Berzuini,
  2. Philip Dawid and
  3. Luisa Bernardinelli
  1. Richard Emsley and
  2. Graham Dunn

Published Online: 25 JUN 2012

DOI: 10.1002/9781119945710.ch20

Causality: Statistical Perspectives and Applications

Causality: Statistical Perspectives and Applications

How to Cite

Emsley, R. and Dunn, G. (2012) Evaluation of Potential Mediators in Randomised Trials of Complex Interventions (Psychotherapies), in Causality: Statistical Perspectives and Applications (eds C. Berzuini, P. Dawid and L. Bernardinelli), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9781119945710.ch20

Editor Information

  1. Statistical Laboratory, Centre for Mathematical Sciences, University of Cambridge, Cambridge, UK

Author Information

  1. Health Sciences Research Group, School of Community Based Medicine, The University of Manchester, Manchester, UK

Publication History

  1. Published Online: 25 JUN 2012
  2. Published Print: 13 JUL 2012

Book Series:

  1. Wiley Series in Probability and Statistics

Book Series Editors:

  1. Walter A. Shewhart and
  2. Samuel S. Wilks

ISBN Information

Print ISBN: 9780470665565

Online ISBN: 9781119945710

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Keywords:

  • potential mediators in randomised trials, SMM and RPMs;
  • mental health, causal using PSDE, SoCRATES in CBT, PANSS score;
  • ITT principle in randomised trials;
  • mediators in psychological treatment trials;
  • CACE, ITT effect within complier subgroup;
  • therapeutic alliance, quantity of sessions and quality of therapeutics;
  • therapy closeness, the actual effect delivered compared with that in manuals;
  • mediators and outcomes, and possibility of measurement errors;
  • traces of hidden selection effects (hidden confounding);
  • CBT effect on outcome, as direct, compared to those on medication

Summary

This chapter contains sections titled:

  • Introduction

  • Potential mediators in psychological treatment trials

  • Methods for mediation in psychological treatment trials

  • Causal mediation analysis using instrumental variables estimation

  • Causal mediation analysis using principal stratification

  • Our motivating example: The SoCRATES trial

  • Conclusions

  • Acknowledgements

  • References