6. Coffee and Parkinson's Disease

  1. Yi-Fang Chu
  1. Jing-Wei Lim1,2 and
  2. Eng-King Tan1,2

Published Online: 6 FEB 2012

DOI: 10.1002/9781119949893.ch6

Coffee: Emerging Health Effects and Disease Prevention

Coffee: Emerging Health Effects and Disease Prevention

How to Cite

Lim, J.-W. and Tan, E.-K. (2012) Coffee and Parkinson's Disease, in Coffee: Emerging Health Effects and Disease Prevention (ed Y.-F. Chu), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781119949893.ch6

Editor Information

  1. Nutrition Research, Kraft Foods, Inc., Glenview, IL, USA

Author Information

  1. 1

    Department of Neurology, Singapore General Hospital, Singapore

  2. 2

    National Neuroscience Institute, Duke Graduate Medical School, Singapore

Publication History

  1. Published Online: 6 FEB 2012
  2. Published Print: 19 MAR 2012

ISBN Information

Print ISBN: 9780470958780

Online ISBN: 9781119949893



  • coffee and PD;
  • motor deficits in PD;
  • nigrostriatal pathway;
  • genetic causes, of PD;
  • double-hit hypothesis;
  • PD, multifactorial etiology


This chapter contains sections titled:

  • Introduction

  • Pathogenesis of Parkinson's disease

  • Gene and environmental/lifestyle factors

  • Clinical evidence linking coffee consumption and Parkinson's disease

  • Neuroprotection and active components of coffee

  • Adenosine receptor antagonism and Parkinson's disease

  • Caffeine rescue of Parkinson's disease in animal models

  • Clinical trials of adenosine receptor antagonists in Parkinson's disease

  • Caffeine-mediated genetic susceptibility of Parkinson's disease

  • Summary

  • Acknowledgments

  • References