10. Hepatobiliary Complications of Hematopoietic Cell Transplantation

  1. Eugene R. Schiff MD, MACP, FRCP3,
  2. Willis C. Maddrey MD, MACP, FRCP4 and
  3. Michael F. Sorrell MD, FACP5
  1. Josh Levitsky MD1 and
  2. Natasha Walzer MD2

Published Online: 31 OCT 2011

DOI: 10.1002/9781119950509.ch10

Schiff's Diseases of the Liver, Eleventh Edition

Schiff's Diseases of the Liver, Eleventh Edition

How to Cite

Levitsky, J. and Walzer, N. (2011) Hepatobiliary Complications of Hematopoietic Cell Transplantation, in Schiff's Diseases of the Liver, Eleventh Edition (eds E. R. Schiff, W. C. Maddrey and M. F. Sorrell), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781119950509.ch10

Editor Information

  1. 3

    Center for Liver Diseases and Schiff Liver Institute, University of Miami Miller School of Medicine, Miami, FL, USA

  2. 4

    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA

  3. 5

    University of Nebraska College of Medicine, Omaha, NE, USA

Author Information

  1. 1

    Division of Hepatology & Comprehensive, Transplant Center, Northwestern University Feinberg School of Medicine, Northwestern Memorial Hospital, Chicago, IL, USA

  2. 2

    Division of Hepatology, University of Illinois at Chicago, Chicago, IL, USA

Publication History

  1. Published Online: 31 OCT 2011
  2. Published Print: 9 DEC 2011

ISBN Information

Print ISBN: 9780470654682

Online ISBN: 9781119950509



  • Graft-versus-host disease;
  • sinusoidal obstruction syndrome;
  • venocclusive disease;
  • hepatitis B virus reactivation;
  • hepatitis C virus;
  • hepatic venous pressure gradient;
  • herpesvirus;
  • cytomegalovirus;
  • Epstein–Barr virus;
  • iron overload


Hepatobiliary disorders are a leading cause of morbidity and mortality following hematopoietic cell transplantation (HCT), even with recent advances in prophylaxis, diagnosis, and treatment. Critical to reducing the incidence of these complications is adequate screening of donors and recipients for prior or active viral infections or evidence of liver disease, as well as close monitoring for signs and symptoms of hepatic dysfunction after HCT. The most common hepatobiliary etiologies include acute and chronic graft-versus-host disease, sinusoidal obstruction syndrome, drug toxicity, infection (bacterial and viral hepatitis), and cholelithiasis. This chapter emphasizes the importance of donor and recipient evaluation and reviews the prevention, diagnosis, and treatment of common and uncommon liver and biliary complications following HCT.