19. Acute Liver Failure

  1. Eugene R. Schiff MD, MACP, FRCP2,
  2. Willis C. Maddrey MD, MACP, FRCP3 and
  3. Michael F. Sorrell MD, FACP4
  1. Anne M. Larson MD, FACP

Published Online: 31 OCT 2011

DOI: 10.1002/9781119950509.ch19

Schiff's Diseases of the Liver, Eleventh Edition

Schiff's Diseases of the Liver, Eleventh Edition

How to Cite

Larson, A. M. (2011) Acute Liver Failure, in Schiff's Diseases of the Liver, Eleventh Edition (eds E. R. Schiff, W. C. Maddrey and M. F. Sorrell), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781119950509.ch19

Editor Information

  1. 2

    Center for Liver Diseases and Schiff Liver Institute, University of Miami Miller School of Medicine, Miami, FL, USA

  2. 3

    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA

  3. 4

    University of Nebraska College of Medicine, Omaha, NE, USA

Author Information

  1. University of Texas Southwestern Medical Center, Dallas, TX, USA

Publication History

  1. Published Online: 31 OCT 2011
  2. Published Print: 9 DEC 2011

ISBN Information

Print ISBN: 9780470654682

Online ISBN: 9781119950509

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Keywords:

  • Acute liver failure;
  • ALF;
  • fulminant liver failure;
  • encephalopathy;
  • liver transplantation;
  • acetaminophen;
  • cerebral edema;
  • hepatic encephalopathy;
  • multiorgan system failure;
  • coagulopathy

Summary

Acute liver failure (ALF) is a devastating syndrome afflicting previously healthy individuals. ALF can swiftly progress to coma and death from cerebral edema and multiorgan system failure. Although it is associated with a variety of causes, the clinical presentation is similar. Early recognition is crucial to its optimal management. Aggressive multidisciplinary management and the judicious use of emergent liver transplantation have improved overall patient survival. Despite significant advances in care, however, the overall mortality remains high. Many patients are not candidates for transplantation or will die of complications before an organ becomes available.