25. Hepatitis C

  1. Eugene R. Schiff MD, MACP, FRCP2,
  2. Willis C. Maddrey MD, MACP, FRCP3 and
  3. Michael F. Sorrell MD, FACP4
  1. Jama M. Darling MD,
  2. Stanley M. Lemon MD and
  3. Michael W. Fried MD

Published Online: 31 OCT 2011

DOI: 10.1002/9781119950509.ch25

Schiff's Diseases of the Liver, Eleventh Edition

Schiff's Diseases of the Liver, Eleventh Edition

How to Cite

Darling, J. M., Lemon, S. M. and Fried, M. W. (2011) Hepatitis C, in Schiff's Diseases of the Liver, Eleventh Edition (eds E. R. Schiff, W. C. Maddrey and M. F. Sorrell), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781119950509.ch25

Editor Information

  1. 2

    Center for Liver Diseases and Schiff Liver Institute, University of Miami Miller School of Medicine, Miami, FL, USA

  2. 3

    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA

  3. 4

    University of Nebraska College of Medicine, Omaha, NE, USA

Author Information

  1. UNC Liver Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

Publication History

  1. Published Online: 31 OCT 2011
  2. Published Print: 9 DEC 2011

ISBN Information

Print ISBN: 9780470654682

Online ISBN: 9781119950509



  • hepatitis C;
  • HAV and HBV infection;
  • sensitive serologic tests;
  • hepatitis C virology;
  • HCV genome, E1 and E2;
  • TLR3 signaling;
  • hepatitis C virus–host;
  • intravenous drug use;
  • interferon, chronic hepatitis C;
  • interferon-free regimens


This chapter contains sections titled:

  • A discovery that changed the practice of hepatology

  • Hepatitis C virus virology

  • Innate immune response to HCV

  • Hepatitis C virus and interferon resistance

  • Epidemiology

  • Risk factors

  • Diagnosis and testing

  • Natural history

  • Histology

  • Therapy

  • References