47. Recurrent Disease Following Liver Transplantation

  1. Eugene R. Schiff MD, MACP, FRCP3,
  2. Willis C. Maddrey MD, MACP, FRCP4 and
  3. Michael F. Sorrell MD, FACP5
  1. Kymberly D. S. Watt MD1 and
  2. Marie A. Laryea MD2

Published Online: 31 OCT 2011

DOI: 10.1002/9781119950509.ch47

Schiff's Diseases of the Liver, Eleventh Edition

Schiff's Diseases of the Liver, Eleventh Edition

How to Cite

Watt, K. D. S. and Laryea, M. A. (2011) Recurrent Disease Following Liver Transplantation, in Schiff's Diseases of the Liver, Eleventh Edition (eds E. R. Schiff, W. C. Maddrey and M. F. Sorrell), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781119950509.ch47

Editor Information

  1. 3

    Center for Liver Diseases and Schiff Liver Institute, University of Miami Miller School of Medicine, Miami, FL, USA

  2. 4

    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA

  3. 5

    University of Nebraska College of Medicine, Omaha, NE, USA

Author Information

  1. 1

    Hepatology & Liver Transplantation, Mayo Clinic Rochester, MN, USA

  2. 2

    Dalhousie University, Halifax, Nova Scotia, Canada

Publication History

  1. Published Online: 31 OCT 2011
  2. Published Print: 9 DEC 2011

ISBN Information

Print ISBN: 9780470654682

Online ISBN: 9781119950509



  • Liver transplantation;
  • recurrent disease;
  • hepatitis C;
  • hepatitis B;
  • autoimmune liver disease;
  • allograft cirrhosis


Liver transplant is the standard of care for eligible patients with end-stage liver disease, acute liver failure, metabolic disorders, and specific hepatic malignancies. Recurrent disease is common after transplant. The frequency of recurrence and the clinical significance of this recurrence varies widely depending on the primary indication for transplantation. This chapter will focus more on the common diseases that recur after transplant, including viral hepatitis, autoimmune hepatitis, and nonalcoholic steatohepatitis. Diseases with less frequent recurrence including alcoholic liver disease, Budd–Chiari syndrome, and metabolic diseases will also be briefly reviewed.