49. Controversies in Liver Transplantation

  1. Eugene R. Schiff MD, MACP, FRCP2,
  2. Willis C. Maddrey MD, MACP, FRCP3 and
  3. Michael F. Sorrell MD, FACP4
  1. James F. Trotter MD

Published Online: 31 OCT 2011

DOI: 10.1002/9781119950509.ch49

Schiff's Diseases of the Liver, Eleventh Edition

Schiff's Diseases of the Liver, Eleventh Edition

How to Cite

Trotter, J. F. (2011) Controversies in Liver Transplantation, in Schiff's Diseases of the Liver, Eleventh Edition (eds E. R. Schiff, W. C. Maddrey and M. F. Sorrell), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781119950509.ch49

Editor Information

  1. 2

    Center for Liver Diseases and Schiff Liver Institute, University of Miami Miller School of Medicine, Miami, FL, USA

  2. 3

    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA

  3. 4

    University of Nebraska College of Medicine, Omaha, NE, USA

Author Information

  1. Baylor University Medical Center, Dallas, TX, USA

Publication History

  1. Published Online: 31 OCT 2011
  2. Published Print: 9 DEC 2011

ISBN Information

Print ISBN: 9780470654682

Online ISBN: 9781119950509



  • Liver transplantation;
  • model for end-stage liver disease;
  • liver allocation;
  • liver distribution;
  • living donor liver transplantation;
  • expanded criteria donor;
  • donor by cardiac death


Liver transplantation generates controversy. In just 25 years, it has evolved from an experimental operation to a standard therapy administered every year to thousands of patients with end-stage liver disease. Despite its widespread application, the procedure is very expensive, risky, and is limited by a critical shortage of donor organs. Consequently, there is ongoing debate about many aspects of liver transplantation. This chapter describes the most topical controversies, including liver allocation and distribution as well as new developments in expanding the donor pool through living donors, expanded criteria donors, and donors by cardiac death.