Metal-Mediated Protein Modification
Published Online: 15 DEC 2011
Copyright © 2011 John Wiley & Sons, Ltd. All rights reserved.
Encyclopedia of Inorganic and Bioinorganic Chemistry
How to Cite
Whittaker, J. W. 2011. Metal-Mediated Protein Modification. Encyclopedia of Inorganic and Bioinorganic Chemistry. .
- Published Online: 15 DEC 2011
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Posttranslational modification of proteins is a general mechanism for regulating biological activity and expanding the functionality in this family of biopolymers. Metal ions have been found to be intimately involved in many of these protein-processing reactions, whether as cofactors of processing metalloenzymes, intrinsic cofactors for self-processing proteins, or protein-targeting solution complexes. A broad range of covalent modifications have been identified as the products of these metal-mediated reactions. Novel amino acid residues resulting from oxygenation, oxidation, or cross-linking side chains play important roles in the structure and reactivity of proteins. In a number of cases, the modified amino acids serve as built-in catalytic cofactors. Reactions of certain metal complexes have been implicated in biomedically important protein modifications, and synthetic complexes have been developed as probes of macromolecular structure. These links underscore the close connections between inorganic and biological chemistry.
- posttranslational modification;