Carbon–Carbon & Carbon–Heteroatom Activation
Published Online: 15 DEC 2011
Copyright © 2011 John Wiley & Sons, Ltd. All rights reserved.
Encyclopedia of Inorganic and Bioinorganic Chemistry
How to Cite
Crabtree, R. H. 2011. Carbon–Carbon & Carbon–Heteroatom Activation. Encyclopedia of Inorganic and Bioinorganic Chemistry. .
- Published Online: 15 DEC 2011
Activation involves binding of the intact CC or CX bond to the metal followed by CC or CX bond cleavage. Both aspects are considered here. The activation of CC bonds is facilitated by an enforced close approach of the CC bond to the metal or by the presence of a strong driving force such as a strained ring starting material or aromatization during the reaction. The reactivity order is: sp–sp > sp2–sp2 > sp3–sp3. The activation of CX bonds occurs by a number of mechanistic pathways depending on the system. Halocarbon complexes of type RXM are often intermediates and can be isolated in favorable cases.