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Metal Nanoparticles: Electronic Properties, Bioresponse, and Synthesis

  1. Günter Schmid

Published Online: 17 DEC 2012

DOI: 10.1002/9781119951438.eibc0284.pub2

Encyclopedia of Inorganic and Bioinorganic Chemistry

Encyclopedia of Inorganic and Bioinorganic Chemistry

How to Cite

Schmid, G. 2012. Metal Nanoparticles: Electronic Properties, Bioresponse, and Synthesis . Encyclopedia of Inorganic and Bioinorganic Chemistry. .

Author Information

  1. University of Duisburg-Essen, Essen, Germany

Publication History

  1. Published Online: 17 DEC 2012

Abstract

This review article considers in the main the interaction of metal nanoparticles (NPs) with biological systems. However, the first part describes electronic properties of metal NPs because of the relevance of the electronic situation in a metal NP and its corresponding physical and chemical properties. Those are of interest if interactions with biological systems are considered, the active centers of which often are also in the nano regime. In particular, the size and shape of metal NPs decisively determine the kind of interactions that are exhibited. The result of such interactions is called “bioresponse”. Bioresponse constitutes the main part of the article, which describes the principles of interactions between NPs and biosystems. Developments in diagnostics and toxicity phenomena are also detailed; these are linked with possible therapeutic attempts, especially in the field of tumor therapy. Finally, an overview is given of the synthetic strategies of NPs. The syntheses of metal NPs are so manifold that only the basic principles are discussed. Primary emphasis is on synthetic procedures that guarantee monodispersity of the NPs and control of their shapes because these properties determine the kind and strength of interaction with biological systems, whether in cell cultures or living animals.

Keywords:

  • electronic properties;
  • bioresponse;
  • toxicity;
  • diagnostics;
  • therapy;
  • syntheses