Medicinal Inorganic Chemistry: Correcting Essential Metal-Ion Deficiencies
Published Online: 15 DEC 2011
Copyright © 2011 John Wiley & Sons, Ltd. All rights reserved.
Encyclopedia of Inorganic and Bioinorganic Chemistry
How to Cite
Thompson, K. H. 2011. Medicinal Inorganic Chemistry: Correcting Essential Metal-Ion Deficiencies. Encyclopedia of Inorganic and Bioinorganic Chemistry. .
- Published Online: 15 DEC 2011
Essential metal ions are those for which there is a known requirement for good health in the body. When dietary intake does not, or cannot, maintain adequate tissue stores of an essential trace or ultratrace metal ion, metal-ion supplementation may be necessary. Simple salts of metal ions are often poorly tolerated, not well absorbed, or too rapidly excreted (or all three of these); therefore, appropriate ligand binding of the particular metal ion can significantly improve the success of supplementation efforts. The most common deficiency disorder, iron-deficiency anemia, is now treated with a number of iron complexes, e.g., Ferrochel™ and ferrous gluconate, that are superior to simple iron salts such as ferrous sulfate; others, such as ferric maltol, are being proposed as useful substitutes. Marginal deficiencies of trace and ultratrace elements, such as zinc, copper, manganese, and chromium, are purported to have long-term negative health effects, especially in aging or ill populations. Defining marginal deficiency is difficult, owing to lack of reliable and accurate biomarkers for the determination of trace element status.
- essential trace metal;
- deficiency disease;
- iron-deficiency anemia;
- dietary reference intake;
- reactive oxygen species