Reaction Coordinate of Pyranopterin Molybdenum Enzymes
Published Online: 15 DEC 2011
Copyright © 2011 John Wiley & Sons, Ltd. All rights reserved.
Encyclopedia of Inorganic and Bioinorganic Chemistry
How to Cite
Kirk, M. L., Knottenbelt, S. and Habtegabre, A. 2011. Reaction Coordinate of Pyranopterin Molybdenum Enzymes. Encyclopedia of Inorganic and Bioinorganic Chemistry.
- Published Online: 15 DEC 2011
Spectroscopic studies on two pyranopterin molybdenum enzymes, sulfite oxidase and xanthine oxidase, have been used to evaluate the results of detailed bonding calculations and provide insight into the reductive half reaction of these enzymes. Specifically, the nature of the reaction coordinate with respect to substrate oxidation appears to be under orbital control, with the inherent electronic structure of the active site playing a key role in the reactivity of these metalloenzymes.
- xanthine oxidase;
- sulfite oxidase;
- reaction coordinate;
- electron paramagnetic resonance;
- magnetic circular dichroism;
- electronic structure;
- density functional theory