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Reaction Coordinate of Pyranopterin Molybdenum Enzymes

  1. Martin L. Kirk,
  2. Sushilla Knottenbelt,
  3. Abebe Habtegabre

Published Online: 15 DEC 2011

DOI: 10.1002/9781119951438.eibc0384

Encyclopedia of Inorganic and Bioinorganic Chemistry

Encyclopedia of Inorganic and Bioinorganic Chemistry

How to Cite

Kirk, M. L., Knottenbelt, S. and Habtegabre, A. 2011. Reaction Coordinate of Pyranopterin Molybdenum Enzymes. Encyclopedia of Inorganic and Bioinorganic Chemistry. .

Author Information

  1. University of New Mexico, Albuquerque, NM, USA

Publication History

  1. Published Online: 15 DEC 2011

Abstract

Spectroscopic studies on two pyranopterin molybdenum enzymes, sulfite oxidase and xanthine oxidase, have been used to evaluate the results of detailed bonding calculations and provide insight into the reductive half reaction of these enzymes. Specifically, the nature of the reaction coordinate with respect to substrate oxidation appears to be under orbital control, with the inherent electronic structure of the active site playing a key role in the reactivity of these metalloenzymes.

Keywords:

  • xanthine oxidase;
  • sulfite oxidase;
  • spectroscopy;
  • reaction coordinate;
  • electron paramagnetic resonance;
  • magnetic circular dichroism;
  • electronic structure;
  • density functional theory