Standard Article

Lanthanides: Magnetic Resonance Imaging

  1. Sophie Laurent,
  2. Luce Vander Elst,
  3. Sebastien Boutry,
  4. Robert N. Muller

Published Online: 17 DEC 2012

DOI: 10.1002/9781119951438.eibc2085

Encyclopedia of Inorganic and Bioinorganic Chemistry

Encyclopedia of Inorganic and Bioinorganic Chemistry

How to Cite

Laurent, S., Vander Elst, L., Boutry, S. and Muller, R. N. 2012. Lanthanides: Magnetic Resonance Imaging. Encyclopedia of Inorganic and Bioinorganic Chemistry. .

Author Information

  1. University of Mons, Mons, Belgium

Publication History

  1. Published Online: 17 DEC 2012

Abstract

Among the different lanthanide ions, gadolinium is the most commonly used to prepare stable complexes for MRI. These paramagnetic complexes are well known as contrast agents (CAs) for MRI. The most widely used ligands for complexation are derivatives of DTPA and DOTA. New CAs are continuously being developed to target specific organs and to allow applications in cellular and molecular MRI. Gd-complexes with high thermodynamic and kinetic stability are required for in vivo applications, giving appropriate biodistribution and safety profiles. The efficiency of MRI CAs is measured in terms of their r1 and r2 relaxivity values.

Keywords:

  • MRI;
  • gadolinium;
  • Gd-complexes;
  • relaxation rates;
  • contrast agents;
  • molecular imaging;
  • Gd-DTPA;
  • Gd-DOTA