Lanthanides: Magnetic Resonance Imaging
Published Online: 17 DEC 2012
Copyright © 2011 John Wiley & Sons, Ltd. All rights reserved.
Encyclopedia of Inorganic and Bioinorganic Chemistry
How to Cite
Laurent, S., Vander Elst, L., Boutry, S. and Muller, R. N. 2012. Lanthanides: Magnetic Resonance Imaging. Encyclopedia of Inorganic and Bioinorganic Chemistry. .
- Published Online: 17 DEC 2012
Among the different lanthanide ions, gadolinium is the most commonly used to prepare stable complexes for MRI. These paramagnetic complexes are well known as contrast agents (CAs) for MRI. The most widely used ligands for complexation are derivatives of DTPA and DOTA. New CAs are continuously being developed to target specific organs and to allow applications in cellular and molecular MRI. Gd-complexes with high thermodynamic and kinetic stability are required for in vivo applications, giving appropriate biodistribution and safety profiles. The efficiency of MRI CAs is measured in terms of their r1 and r2 relaxivity values.
- relaxation rates;
- contrast agents;
- molecular imaging;