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Iron–Sulfur Cluster Biogenesis in Archaea and Bacteria

  1. Harsimranjit K. Chahal1,
  2. Jeff M. Boyd1,
  3. F. Wayne Outten2

Published Online: 5 DEC 2013

DOI: 10.1002/9781119951438.eibc2149

Encyclopedia of Inorganic and Bioinorganic Chemistry

Encyclopedia of Inorganic and Bioinorganic Chemistry

How to Cite

Chahal, H. K., Boyd, J. M. and Outten, F. W. 2013. Iron–Sulfur Cluster Biogenesis in Archaea and Bacteria. Encyclopedia of Inorganic and Bioinorganic Chemistry. 1–27.

Author Information

  1. 1

    Rutgers University, New Brunswick, NJ, USA

  2. 2

    University of South Carolina, Columbia, SC, USA

Publication History

  1. Published Online: 5 DEC 2013

Abstract

Iron–sulfur (Fe–S) clusters are key cofactors required for the activity of essential metalloproteins. Biogenesis of Fe–S clusters is carried out by multiple proteins that work together to mobilize iron and sulfide, assemble nascent clusters, and traffic them to target metalloproteins. While the Isc, Nif, and Suf pathways are the most well-studied Fe–S cluster biogenesis systems, it is clear that a variety of accessory proteins and metabolites cooperate with these systems for cluster assembly. Here, we review the current status of Fe–S cluster biogenesis research in Bacteria and Archaea.

Keywords:

  • Fe–S cluster;
  • Isc;
  • Nif;
  • Suf;
  • ATC;
  • Nfu;
  • Grx;
  • sulfur;
  • iron