Zinc-Dependent Metalloprotease-1 (Zmp1)
Published Online: 23 SEP 2013
Copyright © 2011 John Wiley & Sons, Ltd. All rights reserved.
Encyclopedia of Inorganic and Bioinorganic Chemistry
How to Cite
Ferraris, D. M. and Rizzi, M. 2013. Zinc-Dependent Metalloprotease-1 (Zmp1). Encyclopedia of Inorganic and Bioinorganic Chemistry. 1–7.
- Published Online: 23 SEP 2013
M13 endopeptidases are single-pass, transmembrane zinc-metallopeptidases responsible for the regulation of the biological activity of many hormones and peptides in humans and are involved in many important processes such as blood pressure regulation (neprilysin or NEP), cardiovascular development (endothelin converting enzyme-1 or ECE-1), and prevention of hemolytic reaction (KELL) and phosphate homeostasis (PHEX). Zmp1 is a soluble enzyme member of the M13 endopetidases family, which plays a key role in Mycobacterium tuberculosis pathogenicity through a still to be elucidated mechanism that likely initiates on enzyme secretion.
- zinc-dependent enzymes;
- mycobacterial M13 metalloendopeptidases;
- Mycobacterium tuberculosis ;
- Phagosome maturation