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Cu-Dependent Quercetin Dioxygenase

  1. Roberto A Steiner

Published Online: 23 SEP 2013

DOI: 10.1002/9781119951438.eibc2174

Encyclopedia of Inorganic and Bioinorganic Chemistry

Encyclopedia of Inorganic and Bioinorganic Chemistry

How to Cite

Steiner, R. A. 2013. Cu-Dependent Quercetin Dioxygenase. Encyclopedia of Inorganic and Bioinorganic Chemistry. 1–12.

Author Information

  1. King's College London, London, UK

Publication History

  1. Published Online: 23 SEP 2013

Abstract

Fungal quercetin dioxygenase (Qase) belongs to the cupin superfamily and is the only dioxygenase unambiguously known to rely on a mononuclear Cu(II) center for its catalytic activity. Qase catalyzes the cleavage of the O-heteroaromatic ring of flavonols, yielding the corresponding depside (phenolic carboxylic acid ester) and carbon monoxide. In this review article we explore the available structural and functional information and discuss mechanistic proposals for this unique dioxygenase.

3D Structure

  • original image

    Cartoon representation of Aspergillus japonicus Qase homodimer. The individual subunits are shown in blue and orange with N-linked carbohydrates colored as the subunit they belong to. The copper atoms appear as green spheres. PDB code: 1JUH. This figure and the other structural figures were produced with program PyMOL (http://www.pymol.org).

Keywords:

  • oxygen chemistry;
  • oxygenase;
  • metalloprotein;
  • copper;
  • flavonoids