10. Systematic Reviews of Diagnostic Test Accuracy Studies

  1. Matthew Thompson1,2 and
  2. Ann Van den Bruel2

Published Online: 1 NOV 2011

DOI: 10.1002/9781119951827.ch10

Diagnostic Tests Toolkit

Diagnostic Tests Toolkit

How to Cite

Thompson, M. and Van den Bruel, A. (2011) Systematic Reviews of Diagnostic Test Accuracy Studies, in Diagnostic Tests Toolkit, Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781119951827.ch10

Author Information

  1. 1

    Department of Family Medicine, Oregon Health & Science University, Portland, Oregon, USA

  2. 2

    Department of Primary Care Health Sciences, University of Oxford, Oxford, UK

Publication History

  1. Published Online: 1 NOV 2011
  2. Published Print: 7 OCT 2011

Book Series:

Book Series Editors:

  1. Carl Heneghan,
  2. Rafael Perera and
  3. Douglas Badenoch

ISBN Information

Print ISBN: 9780470657584

Online ISBN: 9781119951827



  • diagnostic test accuracy studies;
  • systematic reviews;
  • definitive accuracy estimate;
  • systematic review questions;
  • electronic databases;
  • thesaurus terms with free text;
  • QUADAS tool;
  • QUADAS interrater reliability;
  • post-test versus pre-test plots;
  • Moses Littenberg summary ROC curve


This chapter contains sections titled:

  • The research question

  • The literature search

  • Assess the quality of individual studies included in the review

  • Summarizing the results of diagnostic studies

  • Combining data and interpreting meta-analyses of diagnostic studies

  • Acknowledgements

  • Further reading