67. Muscle Disorders

  1. Alan J. Sinclair5,6,
  2. Dr John E. Morley7 and
  3. Professor Bruno Vellas8
  1. David Hilton-Jones1,2,3,4

Published Online: 12 MAR 2012

DOI: 10.1002/9781119952930.ch67

Pathy's Principles and Practice of Geriatric Medicine, Volume 1 & 2, Fifth Edition

Pathy's Principles and Practice of Geriatric Medicine, Volume 1 & 2, Fifth Edition

How to Cite

Hilton-Jones, D. (2012) Muscle Disorders, in Pathy's Principles and Practice of Geriatric Medicine, Volume 1 & 2, Fifth Edition (eds A. J. Sinclair, J. E. Morley and B. Vellas), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9781119952930.ch67

Editor Information

  1. 5

    Bedfordshire & Hertfordshire Postgraduate Medical School, University of Bedfordshire, Luton, UK

  2. 6

    Institute of Diabetes for Older People (IDOP), Luton, UK

  3. 7

    Saint Louis University School of Medicine and St Louis Veterans' Affairs Medical Center, St Louis, MO, USA

  4. 8

    Gérontopôle, Toulouse University Hospital and INSERM Unit 558, University of Toulouse III, Toulouse, France

Author Information

  1. 1

    John Radcliffe Hospital, Oxford, UK

  2. 2

    Milton Keynes Hospital Foundation Trust, Milton Keynes, Buckinghamshire, UK

  3. 3

    Muscular Dystrophy Campaign Muscle and Nerve Centre, Oxford, UK

  4. 4

    Myasthenia Gravis Association Myasthenia Centre, Oxford, UK

Publication History

  1. Published Online: 12 MAR 2012
  2. Published Print: 13 APR 2012

ISBN Information

Print ISBN: 9780470683934

Online ISBN: 9781119952930



  • chronic progressive external ophthalmoplegia;
  • dermatomyositis;
  • drug-induced myopathy;
  • endocrine myopathy;
  • inclusion body myositis;
  • myotonic dystrophy;
  • oculopharyngeal muscular dystrophy;
  • polymyositis;
  • statins


Muscle disorders (myopathies) are rare in all age groups. They may be inherited or acquired. Inherited disorders presenting for the first time in middle age and later include myotonic dystrophy, oculopharyngeal muscular dystrophy and mitochondrial disorders, particularly chronic progressive external ophthalmoplegia. Acquired disorders are more common and most are amenable to therapy, an important exception being inclusion body myositis, which is also the most common myopathy presenting over the age of 50 years. The idiopathic inflammatory myopathies, dermatomyositis and polymyositis, respond to immunosuppressant drug therapy. Dermatomyositis may be a paraneoplastic condition and surveillance for cancer is essential. Clinical assessment alone will frequently suggest the correct diagnosis but confirmation may require muscle biopsy or DNA analysis. Drug-induced myopathy is under-recognized but particularly important in the older population because of multiple drug therapy and the explosion in the use of statins.