19. Case–Control Surveillance

  1. Brian L. Strom MD, MPH2,3,4,5,
  2. Stephen E. Kimmel MD, MSCE4,5 and
  3. Sean Hennessy PHARMD, PHD4,5
  1. Lynn Rosenberg,
  2. Patricia F. Coogan and
  3. Julie R. Palmer

Published Online: 3 JAN 2012

DOI: 10.1002/9781119959946.ch19

Pharmacoepidemiology, Fifth Edition

Pharmacoepidemiology, Fifth Edition

How to Cite

Rosenberg, L., Coogan, P. F. and Palmer, J. R. (2012) Case–Control Surveillance, in Pharmacoepidemiology, Fifth Edition (eds B. L. Strom, S. E. Kimmel and S. Hennessy), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781119959946.ch19

Editor Information

  1. 2

    George S. Pepper Professor of Public Health and Preventive Medicine, Philadelphia, PA, USA

  2. 3

    Department of Biostatistics and Epidemiology, Philadelphia, PA, USA

  3. 4

    Center for Clinical Epidemiology and Biostatistics, Philadelphia, PA, USA

  4. 5

    Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

Author Information

  1. Slone Epidemiology Center, Boston University, Boston, MA, USA

Publication History

  1. Published Online: 3 JAN 2012
  2. Published Print: 17 FEB 2012

ISBN Information

Print ISBN: 9780470654750

Online ISBN: 9781119959946



  • cancer;
  • case–control;
  • medication;
  • non-prescription;
  • prescription


There is a need to monitor the long-term health effects of prescription drugs and of non-prescription medications and dietary supplements as well. The Case–Control Surveillance (CCS) study, based on case–control methods, has these capabilities. During 1976–2009, nurse-interviewers administered questionnaires to patients admitted with recently diagnosed cancer or non-malignant illness to participating hospitals to collect information on lifetime history of regular drug use and on risk factors for illness. Discharge summaries and pathology reports were obtained to classify the diagnoses. Information was obtained on 26 823 patients with incident cancers of various sites (e.g., breast, 8002; large bowel, 3124) and 39 622 patients with non-malignant illnesses who serve as controls in case–control analyses of particular exposures and illnesses. CCS has been the basis of 95 publications on medications and other factors in relation to the risk of illness, mainly cancers, and the database is available for the assessment of further hypotheses.