4. Diagnosis

  1. Howard L. Weiner MD2,3,4 and
  2. James M. Stankiewicz MD2,3
  1. James M. Stankiewicz,
  2. Varun Chaubal MD1 and
  3. Guy J. Buckle MD, MPH1,3

Published Online: 23 FEB 2012

DOI: 10.1002/9781119963714.ch4

Multiple Sclerosis: Diagnosis and Therapy

Multiple Sclerosis: Diagnosis and Therapy

How to Cite

Stankiewicz, J. M., Chaubal, V. and Buckle, G. J. (2012) Diagnosis, in Multiple Sclerosis: Diagnosis and Therapy (eds H. L. Weiner and J. M. Stankiewicz), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781119963714.ch4

Editor Information

  1. 2

    Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA

  2. 3

    Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Boston, MA, USA

  3. 4

    Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA, USA

Author Information

  1. 1

    Department of Neurology, Harvard Medical School, Boston, MA, USA

  2. 3

    Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Boston, MA, USA

Publication History

  1. Published Online: 23 FEB 2012
  2. Published Print: 6 APR 2012

ISBN Information

Print ISBN: 9780470654637

Online ISBN: 9781119963714

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Keywords:

  • Revised McDonald criteria;
  • differential diagnosis;
  • radiologically isolated syndrome;
  • clinically isolated syndrome;
  • transverse myelitis;
  • optic neuritis;
  • Sarcoid;
  • Sjogren;
  • Behcet;
  • systemic lupus erthematosus

Summary

The approach to the diagnosis was changed irrevocably with the advent of treatment. Different diagnostic criteria have been proposed, accepted, and revised in time. It remains necessary, however, to exclude a plausible alternate cause. In this chapter we review the currently accepted revised McDonald criteria. We discuss specialized situations including radiologically isolated syndrome, and the concept of MRI negative MS. We also examine differential diagnosis in both relapsing and progressive forms of disease.