12. Sickle Cell Anemia
- John T. Queenan MD2,
- Catherine Y. Spong MD3,
- Charles J. Lockwood MD4
Published Online: 4 JAN 2012
DOI: 10.1002/9781119963783.ch12
Copyright © 2012 John Wiley and Sons, Ltd
Book Title
Queenan's Management of High-Risk Pregnancy: An Evidence-Based Approach, Sixth Edition
Additional Information
How to Cite
Roberts, S. (2012) Sickle Cell Anemia, in Queenan's Management of High-Risk Pregnancy: An Evidence-Based Approach, Sixth Edition (eds J. T. Queenan, C. Y. Spong and C. J. Lockwood), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781119963783.ch12
Editor Information
- 2
Department of Obstetrics and Gynecology, Georgetown University School of Medicine, Washington, DC, USA
- 3
Bethesda, MD, USA
- 4
Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA
Publication History
- Published Online: 4 JAN 2012
- Published Print: 24 FEB 2012
ISBN Information
Print ISBN: 9780470655764
Online ISBN: 9781119963783
- Summary
- Chapter
- References
Keywords:
- maternal disease;
- sickle cell anemia, and homozygous SS genotype;
- sickle cell disease, involving abnormal hemoglobin;
- red blood cells with hemoglobin S undergoing sickling;
- hemolysis of defective RBCs;
- pregnancy, burden to women with sickle hemoglobinopathies;
- hemolysis, viscosity, and VOC;
- hemoglobin SC disease;
- hemoglobin S/β-thalassemia disease
Summary
Sickle cell disease is a member of a family of genetic disorders involving abnormal hemoglobin. The most prevalent hemoglobinopathy is sickle cell anemia resulting from the homozygous SS genotype. Pregnancy is a serious burden to women with sickle hemoglobinopathies, especially those with hemoglobin SS disease. Pregnancy usually results in an increased frequency of sickle cell crises. Infections and pulmonary complications are common. Maternal mortality has decreased dramatically over the years because of improvements in medical care, but remains high.