43. Preterm Premature Rupture of Membranes

  1. John T. Queenan MD3,
  2. Catherine Y. Spong MD4,
  3. Charles J. Lockwood MD5
  1. Brian M. Mercer BA, MD, FRCSC, FACOG1,2

Published Online: 4 JAN 2012

DOI: 10.1002/9781119963783.ch43

Queenan's Management of High-Risk Pregnancy: An Evidence-Based Approach, Sixth Edition

Queenan's Management of High-Risk Pregnancy: An Evidence-Based Approach, Sixth Edition

How to Cite

Mercer, B. M. (2012) Preterm Premature Rupture of Membranes, in Queenan's Management of High-Risk Pregnancy: An Evidence-Based Approach, Sixth Edition (eds J. T. Queenan, C. Y. Spong and C. J. Lockwood), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781119963783.ch43

Editor Information

  1. 3

    Department of Obstetrics and Gynecology, Georgetown University School of Medicine, Washington, DC, USA

  2. 4

    Bethesda, MD, USA

  3. 5

    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA

Author Information

  1. 1

    Division of Maternal-Fetal Medicine, Metro Health Medical Center, OH, USA

  2. 2

    Reproductive Biology, Case Western Reserve University, Cleveland, OH, USA

Publication History

  1. Published Online: 4 JAN 2012
  2. Published Print: 24 FEB 2012

ISBN Information

Print ISBN: 9780470655764

Online ISBN: 9781119963783

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Keywords:

  • preterm premature rupture of membranes (PROM);
  • rupture of fetal membranes, before labor;
  • spontaneous membrane rupture, weakening of membranes;
  • women suffering PPROM, recurrence in future pregnancies;
  • membrane rupture diagnosis, sterile speculum examination;
  • cervical cultures;
  • delivery after PPROM, in clinical chorioamnionitis;
  • management of woman with PROM;
  • cerclage, risk factor for PROM;
  • cessation of leakage with membrane resealing

Summary

Rupture of fetal membranes before the onset of labor (premature rupture of membranes) complicates 8–10% of pregnancies, and is responsible for nearly one-third of preterm births. Premature rupture of membranes, especially preterm premature rupture of membranes, has been associated with brief latency from membrane rupture to delivery, an increased risk of chorio-amnionitis, and umbilical cord compression. As such, preterm premature rupture of membranes is associated with increased risk of perinatal complications. An understanding of gestational age-dependent risks of delivery, the risks and potential benefits of conservative management, and opportunities to reduce complications of preterm birth will help clinicians improve outcomes after this common pregnancy complication.