9. Sexual Aspects of Klinefelter's Syndrome and other Sex-Chromosome Disorders

  1. Mario Maggi
  1. Linda Vignozzi1,
  2. Annamaria Morelli1 and
  3. Mario Maggi2

Published Online: 29 NOV 2011

DOI: 10.1002/9781119963820.ch9

Hormonal Therapy for Male Sexual Dysfunction

Hormonal Therapy for Male Sexual Dysfunction

How to Cite

Vignozzi, L., Morelli, A. and Maggi, M. (2011) Sexual Aspects of Klinefelter's Syndrome and other Sex-Chromosome Disorders, in Hormonal Therapy for Male Sexual Dysfunction (ed M. Maggi), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781119963820.ch9

Editor Information

  1. Sexual Medicine & Andrology, University of Florence, Florence, Italy

Author Information

  1. 1

    Department of Clinical Physiopathology, University of Florence, Florence, Italy

  2. 2

    Sexual Medicine & Andrology, University of Florence, Florence, Italy

Publication History

  1. Published Online: 29 NOV 2011
  2. Published Print: 15 DEC 2011

ISBN Information

Print ISBN: 9780470657607

Online ISBN: 9781119963820

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Keywords:

  • Klinefelter syndrome;
  • sexuality;
  • emotional brain;
  • testosterone;
  • metabolic syndrome;
  • 46,XX male

Summary

KLINEFELTER SYNDROME (KS), first described in 1942 on the basis of testicular failure, occurs in one of 500 to one of 1000 males and is characterized by the abnormal karyotype 47,XXY. The KS phenotype is highly variable, but generally includes testicular failure, tall stature, and characteristic cognitive differences, such as language-based learning disabilities and reading dysfunction. It has been recently reported that, in adulthood, most men with KS will visit their physicians because of 1) infertility and/or 2) sexual dysfunction, suggesting that the clinical setting for the management of sexual problems is a convenient site for the diagnosis of KS. Sexual symptoms eventually present in KS have been demonstrated to be not specifically associated with the syndrome but to the underlying hypogonadal state. Further studies are needed to evaluate the efficacy of testosterone substitution in ameliorating the hypoactive sexual desire often reported in subjects with KS.