12. Obesity and Type 2 Diabetes Mellitus

  1. Charles G. D. Brook MA, MD, FRCP, FRCPCH1 and
  2. Mehul T. Dattani MD, FRCP, FRCPCH, DCH2,3

Published Online: 23 FEB 2012

DOI: 10.1002/9781119968153.ch12

Handbook of Clinical Pediatric Endocrinology, Second Edition

Handbook of Clinical Pediatric Endocrinology, Second Edition

How to Cite

Brook, C. G. D. and Dattani, M. T. (2012) Obesity and Type 2 Diabetes Mellitus, in Handbook of Clinical Pediatric Endocrinology, Second Edition, Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781119968153.ch12

Author Information

  1. 1

    University College London, London, UK

  2. 2

    Developmental Endocrinology Research Group, Clinical and Molecular Genetics Unit, UCL Institute of Child Health, UK

  3. 3

    Great Ormond Street Hospital for Children, London and University College London Hospitals, UK

Publication History

  1. Published Online: 23 FEB 2012
  2. Published Print: 13 APR 2012

ISBN Information

Print ISBN: 9780470657881

Online ISBN: 9781119968153



  • bariatric surgery;
  • BMI;
  • defining obesity;
  • human monogenic obesity syndromes;
  • leptin;
  • metabolic complications of obesity;
  • metabolic syndrome;
  • obesity;
  • pleiotrophic obesity syndromes;
  • prevention of obesity;
  • risks of obesity


This chapter addresses the prevalence of obesity in young people, which has increased dramatically during the past generation; the problem now affects developing as well as industrialized nations and exacts a heavy toll on medical, social and financial sectors. Obesity in children predisposes to adult obesity and to insulin resistance and type 2 diabetes, dyslipidemia, hypertension, hepatic steatosis/steatohepatitis, focal glomerulosclerosis, ovarian hyperandrogenism, gynecomastia, cholecystitis, pancreatitis, pseudotumor cerebri and obstructive sleep apnea. Long-standing obesity in children and adults increases the risks of subsequent cardiovascular disease and some malignancies. Treatment aims to reduce Body Mass Index and fat mass, to normalize glucose tolerance, plasma lipid concentrations, hepatic and renal function and blood pressure, and to prevent or reverse acute and chronic co-morbidities. These objectives can sometimes be achieved through lifestyle intervention (caloric restriction and exercise). Pharmacological agents or surgical intervention may reinforce the effects of diet and exercise and reduce the risk of, or even reverse, complications. In all cases, the social milieu functions as a critical determinant of therapeutic success.